Axonal spheroids and conduction defects in Alzheimer’s disease (Yuan, Zhang, Tong, et al 2022)

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Accession:185864
PAAS (plaque-associated axonal spheroid(s)) are dystrophic structures that sprout from axons that pass through amyloid beta plaques. If small enough they do not interfere with action potential (AP) propagation. Medium sized ones delay APs, and large, or many spheroids can block single APs and block or delay trains of APs.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Pathophysiology; Aging/Alzheimer`s;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]; McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell;