ModelDB: CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)

CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)

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Model Information
Model File
Citations

Accession:187610

"... We examined synaptic connectivity between molecularly defined inhibitory interneurons and CA1 pyramidal cell dendrites using correlative light-electron microscopy and large-volume array tomography. We show that interneurons can be highly selective in their connectivity to specific dendritic branch types and, furthermore, exhibit precisely targeted connectivity to the origin or end of individual branches. Computational simulations indicate that the observed subcellular targeting enables control over the nonlinear integration of synaptic input or the initiation and backpropagation of action potentials in a branchselective manner. Our results demonstrate that connectivity between interneurons and pyramidal cell dendrites is more precise and spatially segregated than previously appreciated, which may be a critical determinant of how inhibition shapes dendritic computation."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells. Neuron 89:1016-30 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):	AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Synaptic Integration;
Implementer(s):	Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];

Search NeuronDB for information about: Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; Gaba; I Na,t; I K;

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activateExcitation.hoc

activateInhibition.hoc

addChannels.hoc *

addExcitation.hoc

addVgatInhibition.hoc

channelParameters.hoc *

flagVgatInhibition.hoc

getBranchOrder.hoc *

idMorph.hoc

inhibitionBiophysics.hoc

initializationAndRun.hoc *

NEURON {
    SUFFIX syns
    RANGE npyAt,npyUnif,sstAt,sstUnif,vlsAt,vgatAt
    RANGE vgatAt,vlnAt,pvAt
    RANGE exc
}

ASSIGNED {
	npyAt
	npyUnif
	sstAt
	sstUnif
	vlsAt
	vgatAt
	vlnAt
	pvAt
	exc
}

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