These files are for the modeling associated with the paper:
Geiger JR, Lubke J, Roth A, Frotscher M, Jonas P.
Submillisecond AMPA receptor-mediated signaling at a principal
Neuron 1997 Jun;18(6):1009-23
Glutamatergic transmission at a principal neuron-interneuron synapse
was investigated by dual whole-cell patch-clamp recording in rat
hippocampal slices combined with morphological analysis. Evoked EPSPs
with rapid time course (half duration = 4 ms; 34 degrees C) were
generated at multiple synaptic contacts established on the interneuron
dendrites close to the soma. The underlying postsynaptic conductance
change showed a submillisecond rise and decay, due to the precise timing
of glutamate release and the rapid deactivation of the postsynaptic AMPA
receptors. Simulations based on a compartmental model of the interneuron
indicated that the rapid postsynaptic conductance change determines the
shape and the somatodendritic integration of EPSPs, thus enabling
interneurons to detect synchronous principal neuron activity.
One can create figures similar to fig8b and fig 8c from the paper by hand once
the program has started. Pressing the "Estimate of fig 8d" button leads to
the generation of a figure similar to the one in the paper. See the fig8d.hoc
file for modifications for higher resolution.
for manual running...
After the mod file is compiled to make the syn2 mechanism available
currentclamp.hoc can be run with the procedure suitable for your platform.