CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)

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Accession:206244
In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Reference:
1 . Müllner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron 87:576-89 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Calcium; I Sodium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Muellner, Fiona E [fiona.muellner at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I h; I Sodium; I Calcium; I Potassium; Gaba; 
% Plot spatial profile of Ca2+-inhibition for strong Ca2+ inhibition (>0.5)
% ---
% Fiona Müllner, MPI Neurobiology
% Email: fiona.muellner at gmail.com

clearvars -except rootfolder
cd(sprintf('%s\\CA1_multi\\experiment\\regular',rootfolder))
list=dir('simulationRes*');

figure

for i=1:size(list,1)
    clearvars -except list i rootfolder
    load(list(i,1).name);
    distv1 = [distv(1:n/2)',distv(1:n/2)'];
    pos1=1;
    fbp=find(branchid(1:n/2-1)>1,1,'first')+1;
    if isempty(fbp)
        chan=n/2+1:n;
    else
        chan=n/2+1:n/2+fbp-1;
    end
    dist = distv1(chan);
    [~,s]=sort(dist);
    yvect = dist(s)-posv(pos1);
    cond1=length(condv);
    time=1:length(timev);
    Inh=1-squeeze(M(pos1,cond1,time,chan(s))./M(pos1,1,time,chan(s)));
    [mv,mp]=max(Inh(:));
    [ix,iy] = ind2sub(size(Inh),mp);
    if ~isnan(iy) && max(Inh(ix,:))>0.5
        plot(yvect,Inh(ix,:),'-');
        hold all
        xlim([-200,200])
    end
end

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