ModelDB: Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

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Accession:20756

This simulation is based on the reference paper listed below. This port was made by Roger D Traub and Maciej T Lazarewicz (mlazarew at seas.upenn.edu) Thanks to Ashlen P Reid for help with porting a morphology of the cell.
Reference:
1 . Traub RD, Buhl EH, Gloveli T, Whittington MA (2003) Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels. J Neurophysiol 89:909-21 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L2/3 pyramidal GLU cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Dendritic Action Potentials; Bursting; Active Dendrites; Detailed Neuronal Models; Axonal Action Potentials; Calcium dynamics;
Implementer(s):	Lazarewicz, Maciej [mlazarew at gmu.edu]; Traub, Roger D [rtraub at us.ibm.com];

Search NeuronDB for information about: Neocortex L2/3 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;

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load_file("nrngui.hoc")
load_file("pyr3.hoc")

Figure 2 ( left )
Figure 2 ( right )
Figure 4 Injection 0.6 nA
Figure 4 Injection 1.1 nA
Figure 4 Injection 1.5 nA
Figure 4 Injection 2.5 nA
Figure 5 B1
Figure 5 B2
Figure 6 B1
Figure 6 B2
Figure 7 g_NaP x 0.0
Figure 7 g_NaP x 0.7
Figure 7 g_NaP x 1.0

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