COMMENT
**************************************************
File generated by: neuroConstruct v1.7.1
**************************************************
This file holds the implementation in NEURON of the Cell Mechanism:
CaV_R_iAMC_ChannelML (Type: Channel mechanism, Model: ChannelML based process)
with parameters:
/channelml/@units = Physiological Units
/channelml/notes = AOB Mitral Cell R-Type Calcium Channel
/channelml/channel_type/@name = CaV_R_iAMC_ChannelML
/channelml/channel_type/status/@value = stable
/channelml/channel_type/status/comment = R-Type Calcium Channel from an intrinsically oscillating AOB mitral cell from parameters recorded in the lab of M. Spehr RWTH Aachen
/channelml/channel_type/status/contributor/name = Simon O'Connor
/channelml/channel_type/notes = A High Voltage Activated Ca2+ channel
/channelml/channel_type/authorList/modelTranslator/name = Simon O'Connor
/channelml/channel_type/authorList/modelTranslator/institution = UH
/channelml/channel_type/authorList/modelTranslator/email = simon.oconnor - at - btinternet.com
/channelml/channel_type/neuronDBref/modelName = Calcium channels
/channelml/channel_type/neuronDBref/uri = http://senselab.med.yale.edu/neurondb/channelGene2.aspx#table1
/channelml/channel_type/current_voltage_relation/@cond_law = ohmic
/channelml/channel_type/current_voltage_relation/@ion = ca
/channelml/channel_type/current_voltage_relation/@default_gmax = 0.15
/channelml/channel_type/current_voltage_relation/@default_erev = 80
/channelml/channel_type/current_voltage_relation/@charge = 2
/channelml/channel_type/current_voltage_relation/@fixed_erev = yes
/channelml/channel_type/current_voltage_relation/gate[1]/@name = m
/channelml/channel_type/current_voltage_relation/gate[1]/@instances = 2
/channelml/channel_type/current_voltage_relation/gate[1]/closed_state/@id = m0
/channelml/channel_type/current_voltage_relation/gate[1]/open_state/@id = m
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@name = tau
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@from = m0
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@to = m
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@expr = v < -30 ? 28.4118 : 3.1738 + (25.238 * (exp(-1 * ((v + 30)/17.498))))
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@name = inf
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@from = m0
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@to = m
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@expr_form = sigmoid
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@rate = 1
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@scale = -2.0914
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@midpoint = -38.037
/channelml/channel_type/current_voltage_relation/gate[2]/@name = h
/channelml/channel_type/current_voltage_relation/gate[2]/@instances = 1
/channelml/channel_type/current_voltage_relation/gate[2]/closed_state/@id = h0
/channelml/channel_type/current_voltage_relation/gate[2]/open_state/@id = h
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@name = tau
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@from = h0
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@to = h
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@expr = v < -30 ? 21.0638148543 : 10.8 + (3.0 * (exp(-1 * ((v+20)/8.13))))
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@name = inf
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@from = h0
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@to = h
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@expr = ((1/(1+(exp(-1 * (v-(-38.037))/-2.0914)))) + (0.6928/(1+(exp(-1 * (v-(-38.037))/2.0914)))))
// File from which this was generated: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/CaV_R_iAMC_ChannelML/CaHVA_Chan.xml
// XSL file with mapping to simulator: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/CaV_R_iAMC_ChannelML/ChannelML_v1.8.1_NEURONmod.xsl
ENDCOMMENT
? This is a NEURON mod file generated from a ChannelML file
? Unit system of original ChannelML file: Physiological Units
COMMENT
AOB Mitral Cell R-Type Calcium Channel
ENDCOMMENT
TITLE Channel: CaV_R_iAMC_ChannelML
COMMENT
A High Voltage Activated Ca2+ channel
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
(um) = (micrometer)
(molar) = (1/liter)
(mM) = (millimolar)
(l) = (liter)
}
NEURON {
SUFFIX CaV_R_iAMC_ChannelML
USEION ca WRITE ica VALENCE 2 ? outgoing current is written
RANGE gmax, gion
RANGE minf, mtau
RANGE hinf, htau
}
PARAMETER {
gmax = 0.00015 (S/cm2) ? default value, should be overwritten when conductance placed on cell
}
ASSIGNED {
v (mV)
celsius (degC)
? Reversal potential of ca
eca (mV)
? The outward flow of ion: ca calculated by rate equations...
ica (mA/cm2)
gion (S/cm2)
minf
mtau (ms)
hinf
htau (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
gion = gmax * (m
^2) * (h
^1)
ica = gion*(v - eca)
}
INITIAL {
eca = 80
rates(v)
m = minf
h = hinf
}
STATE {
m
h
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
h' = (hinf - h)/htau
}
PROCEDURE rates(v(mV)) {
? Note: not all of these may be used, depending on the form of rate equations
LOCAL alpha, beta, tau, inf, gamma, zeta
, temp_adj_m,
A_inf_m, B_inf_m, Vhalf_inf_m
, temp_adj_h
TABLE minf, mtau,hinf, htau
DEPEND celsius FROM -100 TO 100 WITH 400
UNITSOFF
temp_adj_m = 1
temp_adj_h = 1
? *** Adding rate equations for gate: m ***
? Found a generic form of the rate equation for tau, using expression: v < -30 ? 28.4118 : 3.1738 + (25.238 * (exp(-1 * ((v + 30)/17.498))))
if (v < -30 ) {
tau = 28.4118
} else {
tau = 3.1738 + (25.238 * (exp(-1 * ((v + 30)/17.498))))
}
mtau = tau/temp_adj_m
? Found a parameterised form of rate equation for inf, using expression: A / (1 + exp((v-Vhalf)/B))
A_inf_m = 1
B_inf_m = -2.0914
Vhalf_inf_m = -38.037
inf = A_inf_m / (exp((v - Vhalf_inf_m) / B_inf_m) + 1)
minf = inf
? *** Finished rate equations for gate: m ***
? *** Adding rate equations for gate: h ***
? Found a generic form of the rate equation for tau, using expression: v < -30 ? 21.0638148543 : 10.8 + (3.0 * (exp(-1 * ((v+20)/8.13))))
if (v < -30 ) {
tau = 21.0638148543
} else {
tau = 10.8 + (3.0 * (exp(-1 * ((v+20)/8.13))))
}
htau = tau/temp_adj_h
? Found a generic form of the rate equation for inf, using expression: ((1/(1+(exp(-1 * (v-(-38.037))/-2.0914)))) + (0.6928/(1+(exp(-1 * (v-(-38.037))/2.0914)))))
inf = ((1/(1+(exp(-1 * (v-(-38.037))/-2.0914)))) + (0.6928/(1+(exp(-1 * (v-(-38.037))/2.0914)))))
hinf = inf
? *** Finished rate equations for gate: h ***
}
UNITSON
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