COMMENT
**************************************************
File generated by: neuroConstruct v1.7.1
**************************************************
This file holds the implementation in NEURON of the Cell Mechanism:
Kdr_iAMC_ChannelML (Type: Channel mechanism, Model: ChannelML based process)
with parameters:
/channelml/@units = Physiological Units
/channelml/notes = ChannelML file containing a single Channel description
/channelml/channel_type/@name = Kdr_iAMC_ChannelML
/channelml/channel_type/@density = yes
/channelml/channel_type/status/@value = in_progress
/channelml/channel_type/status/comment = Delayed rectifier potassium channel from an inrinsically oscillating AOB mitral cell from parameters recorded in the lab of M. Spehr RWTH Aachen
/channelml/channel_type/status/contributor/name = Simon O'Connor
/channelml/channel_type/notes = Mitral cell K DR channel
/channelml/channel_type/neuronDBref/modelName = K channels
/channelml/channel_type/neuronDBref/uri = http://senselab.med.yale.edu/neuronDB/channelGene2.aspx#table3
/channelml/channel_type/current_voltage_relation/@cond_law = ohmic
/channelml/channel_type/current_voltage_relation/@ion = k
/channelml/channel_type/current_voltage_relation/@default_gmax = 1.0
/channelml/channel_type/current_voltage_relation/@default_erev = -86.5
/channelml/channel_type/current_voltage_relation/@charge = 1
/channelml/channel_type/current_voltage_relation/gate[1]/@name = m
/channelml/channel_type/current_voltage_relation/gate[1]/@instances = 1
/channelml/channel_type/current_voltage_relation/gate[1]/closed_state/@id = m0
/channelml/channel_type/current_voltage_relation/gate[1]/open_state/@id = m
/channelml/channel_type/current_voltage_relation/gate[1]/open_state/@fraction = 1
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@name = tau
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@from = m0
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@to = m
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[1]/time_course/@expr = v < -66.67 ? 230.256604897 : 29.156*exp(-(v+55)/5.8842) + 18.394
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@name = inf
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@from = m0
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@to = m
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[1]/steady_state/@expr = v < -66.67 ? 0 : 0.005*v + 0.35
/channelml/channel_type/current_voltage_relation/gate[2]/@name = n
/channelml/channel_type/current_voltage_relation/gate[2]/@instances = 1
/channelml/channel_type/current_voltage_relation/gate[2]/closed_state/@id = n0
/channelml/channel_type/current_voltage_relation/gate[2]/open_state/@id = n
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@name = tau
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@from = n0
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@to = n
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[2]/time_course/@expr = 1.5
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@name = inf
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@from = n0
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@to = n
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@expr_form = generic
/channelml/channel_type/current_voltage_relation/gate[2]/steady_state/@expr = v < 5 ? 0 : ((-0.006*v) + 0.40)
/channelml/channel_type/impl_prefs/table_settings/@max_v = 100
/channelml/channel_type/impl_prefs/table_settings/@min_v = -100
/channelml/channel_type/impl_prefs/table_settings/@table_divisions = 400
// File from which this was generated: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/Kdr_iAMC_ChannelML/KChannel.xml
// XSL file with mapping to simulator: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/Kdr_iAMC_ChannelML/ChannelML_v1.8.1_NEURONmod.xsl
ENDCOMMENT
? This is a NEURON mod file generated from a ChannelML file
? Unit system of original ChannelML file: Physiological Units
COMMENT
ChannelML file containing a single Channel description
ENDCOMMENT
TITLE Channel: Kdr_iAMC_ChannelML
COMMENT
Mitral cell K DR channel
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
(um) = (micrometer)
(molar) = (1/liter)
(mM) = (millimolar)
(l) = (liter)
}
NEURON {
SUFFIX Kdr_iAMC_ChannelML
USEION k READ ek WRITE ik VALENCE 1 ? reversal potential of ion is read, outgoing current is written
RANGE gmax, gion
RANGE minf, mtau
RANGE ninf, ntau
}
PARAMETER {
gmax = 0.001 (S/cm2) ? default value, should be overwritten when conductance placed on cell
}
ASSIGNED {
v (mV)
celsius (degC)
? Reversal potential of k
ek (mV)
? The outward flow of ion: k calculated by rate equations...
ik (mA/cm2)
gion (S/cm2)
minf
mtau (ms)
ninf
ntau (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
gion = gmax * ((1*m)
^1) * (n
^1)
ik = gion*(v - ek)
}
INITIAL {
ek = -86.5
rates(v)
m = minf
n = ninf
}
STATE {
m
n
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
n' = (ninf - n)/ntau
}
PROCEDURE rates(v(mV)) {
? Note: not all of these may be used, depending on the form of rate equations
LOCAL alpha, beta, tau, inf, gamma, zeta
, temp_adj_m
, temp_adj_n
TABLE minf, mtau,ninf, ntau
DEPEND celsius FROM -100 TO 100 WITH 400
UNITSOFF
temp_adj_m = 1
temp_adj_n = 1
? *** Adding rate equations for gate: m ***
? Found a generic form of the rate equation for tau, using expression: v < -66.67 ? 230.256604897 : 29.156*exp(-(v+55)/5.8842) + 18.394
if (v < -66.67 ) {
tau = 230.256604897
} else {
tau = 29.156*exp(-(v+55)/5.8842) + 18.394
}
mtau = tau/temp_adj_m
? Found a generic form of the rate equation for inf, using expression: v < -66.67 ? 0 : 0.005*v + 0.35
if (v < -66.67 ) {
inf = 0
} else {
inf = 0.005*v + 0.35
}
minf = inf
? *** Finished rate equations for gate: m ***
? *** Adding rate equations for gate: n ***
? Found a generic form of the rate equation for tau, using expression: 1.5
tau = 1.5
ntau = tau/temp_adj_n
? Found a generic form of the rate equation for inf, using expression: v < 5 ? 0 : ((-0.006*v) + 0.40)
if (v < 5 ) {
inf = 0
} else {
inf = ((-0.006*v) + 0.40)
}
ninf = inf
? *** Finished rate equations for gate: n ***
}
UNITSON
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