A model of cerebellar LTD including RKIP inactivation of Raf and MEK (Hepburn et al 2017)

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Accession:222732
An updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) and Raf kinase are added to an earlier published model. Calcium dynamics is updated as a constant-rate influx to more closely match experiment. AMPA receptor interactions are improved by adding phosphorylation and dephosphorylation of AMPA receptors when bound to glutamate receptor interacting protein (GRIP). The model is tuned to reproduce experimental calcium peak vs LTD amplitude curves accurately at 4 different calcium pulse durations.
Reference:
1 . Hepburn I, Jain A, Gangal H, Yamamoto Y, Tanaka-Yamamoto K, De Schutter E (2017) A model of induction of cerebellar Long-Term Depression including RKIP inactivation of Raf and MEK Frontiers in Molecular Neuroscience
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Molecular Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: STEPS;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Hepburn, Iain [ihepburn at oist.jp]; Jain, Anant [anantdavinci at gmail.com]; Gangal, Himanshu [himanshugangal at gmail.com];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; AMPA;
 
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LTD_STEPS_2.1
README.html
LTD_STEPS_2.1.py
                            
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