Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)

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Accession:223649
" ... We hypothesized that currents are grouped into distinct modules that shape specific neuronal characteristics or signatures, such as resting potential, sub-threshold oscillations, and spiking waveforms, for several classes of neurons. For such a grouping to occur, the currents within one module should have minimal functional interference with currents belonging to other modules. This condition is satisfied if the gating functions of currents in the same module are grouped together on the voltage axis; in contrast, such functions are segregated along the voltage axis for currents belonging to different modules. We tested this hypothesis using four published example case models and found it to be valid for these classes of neurons. ..."
Reference:
1 . Alturki A, Feng F, Nair A, Guntu V, Nair SS (2016) Distinct current modules shape cellular dynamics in model neurons. Neuroscience 334:309-331 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Amygdala;
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Activity Patterns; Oscillations; Methods; Olfaction;
Implementer(s):
/
AlturkiEtAl2016
3_Mitral
Original
readme.txt *
cadecay.mod *
Ih.mod *
INaP.mod
kA.mod
kca3.mod
kfasttab.mod *
kO.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod
kfast_k.inf *
kfast_k.tau *
kfast_k.txt *
kfast_n.inf *
kfast_n.tau *
kfast_n.txt *
kslow_k.inf *
kslow_k.tau *
kslow_k.txt *
kslow_n.inf *
kslow_n.tau *
kslow_n.txt *
mitral.hoc
mosinit.hoc *
tabchannels.hoc *
                            
// tabchannels.hoc
// Tabulated channels for Kfast and Kslow channels
//
// Implemented in Rubin and Cleland (2006) J Neurophysiology
// Written by Andrew Davison, The Babraham Institute, 17 August 1998
// 	[Davison AP, Feng J, Brown D (2000) Brain Res Bulletin 51(5):393-399]
// Derived from Bhalla and Bower (1993) J Neurophysiology


//*************************************************************************
// Reading function tables for tabchannels
//*************************************************************************

// kfasttab
objref tabkinfvec, tabninfvec, tabktauvec, tabntauvec, vvec
clipboard_retrieve("kfast_k.inf")
tabkinfvec = hoc_obj_[0]
vvec = hoc_obj_[1]
clipboard_retrieve("kfast_n.inf")
tabninfvec = hoc_obj_[0]
clipboard_retrieve("kfast_k.tau")
tabktauvec = hoc_obj_[0]
clipboard_retrieve("kfast_n.tau")
tabntauvec = hoc_obj_[0]
table_tabkinf_kfasttab(&tabkinfvec.x[0], vvec.size, &vvec.x[0])
table_tabninf_kfasttab(&tabninfvec.x[0], vvec.size, &vvec.x[0])
table_tabktau_kfasttab(&tabktauvec.x[0], vvec.size, &vvec.x[0])
table_tabntau_kfasttab(&tabntauvec.x[0], vvec.size, &vvec.x[0])

//kslowtab
objref tabkinfvecs, tabninfvecs, tabktauvecs, tabntauvecs
clipboard_retrieve("kslow_k.inf")
tabkinfvecs = hoc_obj_[0]
clipboard_retrieve("kslow_n.inf")
tabninfvecs = hoc_obj_[0]
clipboard_retrieve("kslow_k.tau")
tabktauvecs = hoc_obj_[0]
clipboard_retrieve("kslow_n.tau")
tabntauvecs = hoc_obj_[0]
table_tabkinf_kslowtab(&tabkinfvecs.x[0], vvec.size, &vvec.x[0])
table_tabninf_kslowtab(&tabninfvecs.x[0], vvec.size, &vvec.x[0])
table_tabktau_kslowtab(&tabktauvecs.x[0], vvec.size, &vvec.x[0])
table_tabntau_kslowtab(&tabntauvecs.x[0], vvec.size, &vvec.x[0])

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