ModelDB: Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)

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Accession:223891

" ... Here, combining data from fluorescence-targeted dendritic recordings and Ca2+ imaging from low-threshold spiking cells in rat brain slices with computational modeling, the cellular mechanism responsible for LTS (Low Threshold Spike) generation is established. ..." " ... Using dendritic recording, 2-photon glutamate uncaging, and computational modeling, we investigated how rat dorsal lateral geniculate nucleus thalamocortical neurons integrate excitatory corticothalamic feedback. ..."
References:
1 . Connelly WM, Crunelli V, Errington AC (2016) Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites. J Neurosci 36:3735-54 [PubMed]
2 . Connelly WM, Crunelli V, Errington AC (2015) The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons. J Neurosci 35:15505-22 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Thalamus;
Cell Type(s):	Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s):	I T low threshold; I Calcium; I h;
Gap Junctions:
Receptor(s):	NMDA; AMPA;
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Active Dendrites; Action Potential Initiation; Calcium dynamics;
Implementer(s):	Connelly, William [connelly.bill at gmail.com];