COREM: configurable retina simulator (Martínez-Cañada et al., 2016)

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COREM is a configurable simulator for retina modeling that has been implemented within the framework of the Human Brain Project (HBP). The software platform can be interfaced with neural simulators (e.g., NEST) to connect with models of higher visual areas and with the Neurorobotics Platform of the HBP. The code is implemented in C++ and computations of spatiotemporal equations are optimized by means of recursive filtering techniques and multithreading. Most retina simulators are more focused on fitting specific retina functions. By contrast, the versatility of COREM allows the configuration of different retina models using a set of basic retina computational primitives. We implemented a series of retina models by combining these primitives to characterize some of the best-known phenomena observed in the retina: adaptation to the mean light intensity and temporal contrast, and differential motion sensitivity. The code has been extensively tested in Linux. The software can be also adapted to Mac OS. Installation instructions as well as the user manual can be found in the Github repository:
1 . Martínez-Cañada P, Morillas C, Pino B, Ros E, Pelayo F (2016) A Computational Framework for Realistic Retina Modeling. Int J Neural Syst 26:1650030 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina bipolar GLU cell; Retina photoreceptor cone GLU cell; Retina ganglion GLU cell; Retina amacrine cell; Retina horizontal cell;
Gap Junctions:
Simulation Environment: C or C++ program;
Model Concept(s): Vision;
Implementer(s): Martínez-Cañada, Pablo [pablomc at]; Carrillo, Richard R. [rcarrillo at];
Search NeuronDB for information about:  Retina ganglion GLU cell; Retina photoreceptor cone GLU cell; Retina bipolar GLU cell;
%INRPLOT loads an INR file and plots its content graphically
%   This function allows the user to partially read a INR file and plot
%   part of its content in different modes.
%   INRPLOT filename mode
%   load the whole INR filename file and plot it in mode mode.
%   If additional arguments are specified, only a specific part of the
%   file is loaded:
%   INRPLOT filename mode x_ini x_end only reads (and plot) an interval of
%   pixel columns from all source images (from column x_ini to column x_end).
%   First column coordinate is number zero.
%   INRPLOT filename mode x_ini x_end y_ini y_end only reads a square from 
%   all source images (from column x_ini to column x_end and from row x_ini
%   to row x_end).
%   INRPLOT filename mode x_ini x_end y_ini y_end z_ini z_end only reads a
%   square from a specific interval of source images (from frame z_ini to
%   frame z_end). First frame is number zero.
%   INRPLOT filename mode x_ini x_end y_ini y_end z_ini z_end v_ini v_end
%   only reads a subset of color channels of a square from a specific
%   interval of source frames. First channel is number zero.
%   Inf can be specified as end coordinate value to indicate that we want to
%   load up to the last coordinate in file.
%   mode can be:
%     mo: to play the images as a movie
%     pl: to plot the evolution of each pixel magnitude as a graph curve,
%     that is, pixel magnitude versus frame number.
%     If the number of frames is only one, it plots the pixel magnitude
%     versus the X coordinate (or Y if we have more Y coordinates than X
%     coordinate) of the pixel. That is, one curve per row (or column).
%     ra: to plot a raster plot of the magnitude of specified pixels
%   For example:
%   inrplot 'sequence.inr'  mo  0 Inf  0 Inf  0 99
%   it loads the 100 first complete frames and play them as a movie.
%   inrplot 'sequence.inr'  pl  4 4  5 5
%   it plots the evolution of the magnitude of pixel (4,5) through the simulation.
%   inrplot 'sequence.inr'  pl  0 Inf  Inf Inf  100 100
%   it plots the magnitude of pixels of last image row in frame 100
%   inrplot 'sequence.inr'  pl  10 11  0 Inf  100 100
%   it plots the pixel magnitudes of rows 10 and 11 of frame 100
%   inrplot 'sequence.inr'  ra  0 Inf  10 10
%   it plots a raster plot of pixel magnitudes of row 10. That is, it shows
%   all pixel magnitudes versus frame number.
%   See also INRLOAD.

%   Copyright (C) 2016 by Richard R. Carrillo 
%   $Revision: 1.3 $  $Date: 2/11/2016 $

%   This program is free software; you can redistribute it and/or modify
%   it under the terms of the GNU General Public License as published by
%   the Free Software Foundation; either version 3 of the License, or
%   (at your option) any later version.
function inrplot(varargin)


if nargs ~= 2 && nargs ~= 4 && nargs ~= 6 && nargs ~= 8 && nargs ~= 10
      disp('You must specify 2, 4, 6, 8 or 10 arguments');
      disp('inrload filename mode [x_ini x_end [y_ini y_end [z_ini z_end]]]');
      disp('All arguments must be numeric except the first two ones')
      disp('type: help inrplot for more help');
      error('Incorrect number of input arguments')
    filename = varargin{1};
    mode = varargin{2};

    % If fn argument dimension data types are strings, convert to doubles
    % The type may change denpending on how the fn is called: as fn or script
    for arg_ind=3:nargs
        if isa(varargin{arg_ind},'char')
            vargs_num(arg_ind-2) = str2double(varargin{arg_ind});
            vargs_num(arg_ind-2) = varargin{arg_ind};

    user_dim_size = [zeros(1,N_dims) ; ones(1,N_dims)*Inf]; % Default dimension coordinates of data to load: load all data: 0 -> Inf
    % Replace dim_size values with the dimension limits specified by user
    for arg_ind=1:(nargs-2)/2 % Parse input dimension coordenate intervals
        user_dim_size(:,arg_ind) = [vargs_num(arg_ind*2 - 1) vargs_num(arg_ind*2)];

    user_dim_size_cell = num2cell(user_dim_size(:)); % Convert array into an array of cells in order to pass these numbers as arguments to the inrload fn
    % Load images and specific coordinates of first and last read pixel for each matrix dimension
    [images, read_dim_size] = inrload(filename, user_dim_size_cell{:}); % Load all required data from file
    if ~isempty(images) % File successfully read
        fprintf(1,'Dimensions of read data (X,Y,Z,V): %i x %i x %i x %i\n', arrayfun( @(dim) (size(images,dim)), 1:N_dims));
        if ~strcmp(mode,'mo') && size(images,4) > 1
            warning('Fourth dimension (V) of data in input file should only have 1 coordinate (that is, the file should contain escalar pixels). Using only the first V coordinate.')

        switch mode
            case 'mo'
                images = permute(images,[2 1 4 3]); % for immovie image must be an M-by-N-by-1-by-K array, where K is the number of images
                if size(images,3) == 1 % grayscaled frames
                    % normalize pixel values to interval 1 255
                    images = images - min(images(:));
                    images = 1 + double(images)/double(max(images(:)))*255;
                    images_mov = immovie(images,gray(256));
                    if size(images,3) == 3 % color frames
                        images_mov = immovie(images);
                        error('Input frames must be grayscaled (V dim. size = 1) or true color (V dim. size = 3)')
            case 'pl'
                if size(images,3) ~= 1 % If we have several frames, plot magnitudes versus frame number
                    % Arrange each image pixel evolution as a row vector
                    pixel_vect=reshape(images, [size(images,1)*size(images,2) size(images,3)]); % first matrix dimension (image row) traveled first
                    plot(read_dim_size(1,3):read_dim_size(2,3), pixel_vect') % plot one curve per pixel (row of pixel_vect)
                    title('Evolution of pixel magnitudes')
                    ylabel('activaton level')
                    % Calculate the label for each plot curve (image pixel evolution)
                    x_coord=repmat((read_dim_size(1,1):read_dim_size(2,1))', 1, read_dim_size(2,2)-read_dim_size(1,2)+1); % x coord. of the labels
                    y_coord=repmat(read_dim_size(1,2):read_dim_size(2,2), read_dim_size(2,1)-read_dim_size(1,1)+1, 1); % y coord. of the labels
                    pixel_labels=arrayfun(@(x,y)(sprintf('(%i,%i)',x,y)), x_coord, y_coord, 'UniformOutput', false);
                else % If we have only one frame, plot magnitudes versus pixel coordinate
                    if size(images,1) >= size(images,2) % If we have X coordinate and y coordinates, plot magnitudes versus X coordinates
                        plot(read_dim_size(1,1):read_dim_size(2,1), images') % plot one curve per pixel (row of pixel_vect)
                        title(['Pixel magnitudes in frame ' num2str(read_dim_size(1,3))])
                        xlabel('X coordinate')
                        ylabel('activaton level')
                        % Calculate the label for each plot curve (image row)
                        pixel_labels=arrayfun(@(y)(sprintf('row %i',y)), read_dim_size(1,2):read_dim_size(2,2), 'UniformOutput', false);
                    else % If we have more Y coordinate than X coordinates, plot magnitudes versus Y coordinates
                        plot(read_dim_size(1,2):read_dim_size(2,2), images) % plot one curve per pixel (row of pixel_vect)
                        title(['Pixel magnitudes in frame ' num2str(read_dim_size(1,3))])
                        xlabel('Y coordinate')
                        ylabel('activaton level')
                        % Calculate the label for each plot curve (image row)
                        pixel_labels=arrayfun(@(x)(sprintf('col. %i',x)), read_dim_size(1,1):read_dim_size(2,1), 'UniformOutput', false);
            case 'ra'
                % Arrange image pixels as row vectors
                pixel_vect=reshape(images, [size(images,1)*size(images,2) size(images,3)]);
                imagesc(read_dim_size(1,3):read_dim_size(2,3), 1:(read_dim_size(2,1)-read_dim_size(1,1)+1)*(read_dim_size(2,2)-read_dim_size(1,2)+1), pixel_vect);
                % set(gca,'XTick', read_dim_size(1,3):read_dim_size(2,3)) % Show all frame numbers
                title('Evolution of pixel magnitudes')
                ylabel(sprintf('pixel index from (%i,%i) to (%i,%i)',read_dim_size(:,1:2)'))

            case 'hi'
                % Determine a proper number of histogram bins according to the num. of pixels
                if tot_pixels < 1000
                    n_bins = 10;
                    if tot_pixels > 100000
                        n_bins = 1000;
                        n_bins = tot_pixels/200;

                hist(double(images(:)), n_bins);
                xlabel('pixel magnitude');
                ylabel('pixel count');
                error('Unknown plot mode specified.')
        error('No data could be loaded.')

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