Cerebellar granular layer (Maex and De Schutter 1998)

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Accession:227363
Circuit model of the granular layer representing a one-dimensional array of single-compartmental granule cells (grcs) and Golgi cells (Gocs). This paper examines the effects of feedback inhibition (grc -> Goc -> grc) versus feedforward inhibition (mossy fibre -> Goc -> grc) on synchronization and oscillatory behaviour.
Reference:
1 . Maex R, De Schutter E (1998) Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J Neurophysiol 80:2521-37 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule GLU cell; Cerebellum golgi cell;
Channel(s): I Na,t; I A; I h; I K,Ca; I L high threshold; I_KD;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Oscillations;
Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I h; I K,Ca; I_KD; Gaba; Glutamate;
// Morphology file for Golgi cell
// A single compartment neuron with a spherical soma yielding
// an Rin (78 MegaOhm) and a time-constant (24 msec) as tabulated in Midtgaard (1992).
// The resulting Cm is 0.31 nF, assuming a specific membrane capacitance of 0.01 (F/m^2).
// The resulting surface area is 0.31e5 um^2.
// Written by RM (27/11/95).
// changed /library/soma to /library/interneuron/soma on 16/4/96 MAEX

   
*relative

*set_compt_param ELEAK {ELEAK}
*set_compt_param EREST_ACT {EREST_ACT}
   *set_compt_param RM	3.03 // 2.4000	// 24 000 ohm.cm^2
*set_compt_param RA	1.0000 	// 
*set_compt_param CM	0.0100	// 1microF/cm^2

*compt /library/interneuron/soma
   soma		none		0.000	0.000	0.000	30.0 // 99.33


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