ModelDB: L4 cortical barrel NN model receiving thalamic input during whisking or touch (Gutnisky et al. 2017)

L4 cortical barrel NN model receiving thalamic input during whisking or touch (Gutnisky et al. 2017)

Download zip file
Help downloading and running models

Model Information
Model File
Citations

Accession:228596

Excitatory neurons in layer 4 (L4) in the barrel cortex respond relatively strongly to touch but not to whisker movement (Yu et al., Nat. Neurosci. 2016). The model explains the mechanism underlying this effect. The network is settled to filter out most stationary inputs. Brief touch input passes through because it takes time until feed-forward inhibition silences excitatory neurons receiving brief and strong thalamic excitation.
Reference:
1 . Gutnisky DA, Yu J, Hires SA, To MS, Bale M, Svoboda K, Golomb D (2017) Mechanisms underlying a thalamocortical transformation during active tactile sensation PLoS Comput Biol 13(6):e1005576

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:	Barrel cortex; Mouse;
Cell Type(s):	Neocortex layer 4 neuron; Abstract Wang-Buzsaki neuron;
Channel(s):	I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Glutamate; Gaba;
Simulation Environment:	C or C++ program;
Model Concept(s):	Sensory processing; Touch; Whisking;
Implementer(s):	Golomb, David [golomb at bgu.ac.il];