" ... Here, we use a
modeling approach to investigate whether and how the morphology of the
basal tree mediates the functional output of neurons. We implemented
57 basal tree morphologies of layer 5 prefrontal pyramidal neurons of
the rat and identified morphological types which were characterized by
different response features, forming distinct functional types. These
types were robust to a wide range of manipulations (distribution of
active ionic mechanisms, NMDA conductance, somatic and apical tree
morphology or the number of activated synapses) and supported
different temporal coding schemes at both the single neuron and the
microcircuit level.
We predict that the basal tree morphological
diversity among neurons of the same class mediates their segregation
into distinct functional pathways.
..."
Reference:
1 .
Papoutsi A, Kastellakis G, Poirazi P (2017) Basal tree complexity shapes functional pathways in the prefrontal cortex. J Neurophysiol 118:1970-1983 [PubMed]
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