2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)

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Accession:232097
This is a biophysical model of the olfactory bulb (OB) that contains three types of neurons: mitral cells, granule cells and periglomerular cells. The model is used to study the cellular and synaptic mechanisms of OB gamma oscillations. We concluded that OB gamma oscillations can be best modeled by the coupled oscillator architecture termed pyramidal resonance inhibition network gamma (PRING).
Reference:
1 . Li G, Cleland TA (2017) A coupled-oscillator model of olfactory bulb gamma oscillations. PLoS Comput Biol 13:e1005760 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron periglomerular GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Olfaction;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; GabaA; AMPA; NMDA;
%==========================================================================
% Written by Guosh Li (guoshi_li@med.unc.edu) 
% Plot PG-->MC and GC-->MC GABAA conductance in the OB network
% Simulation time needs to be 3000 ms (3 sec) for the m-file to run properly
%==========================================================================

clc;
clear all;
close all;

DT = 0.2;    % sampling time: ms
T1 = 1000;
T2 = 3000;
n1 = T1/DT+2;
n2 = T2/DT;


nmitx = 5;
nmity = 5;

nMit = 25;
nPG  = 25;
nGC  = 100;

load tt;
t  = tt(n1:n2);
t = (t-2000);

% Load PG-->MC conductances
for i = 0:1:nmitx-1
    for j = 0:1:nmity-1
     s = ['load Gpm' int2str(i) int2str(j) ';'];    
     eval(s);
     s = ['U=Gpm' int2str(i) int2str(j) ';'];
     eval(s);
     U = U(n1:n2);
     s = ['Gpm' int2str(i) int2str(j) '=U*1e3'  ';'];
     eval(s);

    end
end


% Load GC-->MC conductances

  for i = 0:1:(nMit-1) 
     s = ['load Ggm' int2str(i) ';'];    
     eval(s);
     s = ['U=Ggm' int2str(i) ';'];
     eval(s);
     U = U(n1:n2);
     s = ['Ggm' int2str(i) '=U*1e3'  ';'];
     eval(s);
  end


%================================================
%               For PG-->MC 
%================================================

    figure;
    subplot(3,1,1);
    plot(t,Gpm00,'b-');
    title('G_P_G_-_-_>_M_C', 'FontSize',14);
    set(gca, 'XTickLabel',[ ]);
    set(gca, 'FontSize',12);
    box('off');

    subplot(3,1,2);
    plot(t,Gpm23,'b');
    set(gca, 'XTickLabel',[ ]);
    set(gca, 'FontSize',12);
    ylabel('nS', 'FontSize',14);
    box('off');

    subplot(3,1,3);
    plot(t,Gpm34,'b');
    set(gca, 'FontSize',12);
    xlabel('ms', 'FontSize',14);
    box('off');


%=====================================
%           For GC-->MC 
%=====================================

    xmax = 1001;
    ymax = 80;
%     
%     figure;
%     subplot(3,1,1);
%     plot(t,Ggm0,'b','LineWidth',2);
%     set(gca, 'XTickLabel',[ ]);
%     set(gca, 'FontSize',12);
%     axis([-0.2,xmax,0,ymax]);
%     % set(gca, 'YTick',[0:15:30]);
%     title('G_G_C_-_>_M_C', 'FontSize',14);
% %     legend('MC1');
%     box('off');
% 
%     subplot(3,1,2);
%     plot(t,Ggm14,'b','LineWidth',2);
%     set(gca, 'XTickLabel',[ ]);
%     set(gca, 'FontSize',12);
%     axis([-0.2,xmax,0,ymax]);
%     % set(gca, 'YTick',[0:15:30]);
%     ylabel('nS', 'FontSize',14);
% %     legend('MC13');
%     box('off');
% 
%     subplot(3,1,3);
%     plot(t,Ggm20,'b','LineWidth',2);
%     set(gca, 'FontSize',12);
%     xlabel('Sec', 'FontSize',14);
%     axis([-0.2, xmax, 0, ymax]);
%     % set(gca, 'YTick',[0:15:30]);
% %        legend('MC24');
%     box('off');
    
    
    
    figure;
    plot(t,Ggm0,'b', t,Ggm14, 'r', t,Ggm20,'k','LineWidth',2);
    set(gca, 'FontSize',12);
    axis([-200,800,0,ymax]);
    xlabel('ms', 'FontSize',14);
    ylabel('nS', 'FontSize',14);
    title('G_G_C_-_-_>_M_C', 'FontSize',14);
    box('off');

    
    
    
    
    
    
    








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