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A model for recurrent spreading depolarizations (Conte et al. 2017)
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A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for cortical spreading depolarizations. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.
Conte C, Lee R, Sarkar M, Terman D (2018) A mathematical model of recurrent spreading depolarizations.
J Comput Neurosci
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Neuron or other electrically excitable cell;
I Cl, leak;
Detailed Neuronal Models;
Terman, David [terman at math.ohio-state.edu];
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I Cl, leak
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