A model for recurrent spreading depolarizations (Conte et al. 2017)

 Download zip file 
Help downloading and running models
A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for cortical spreading depolarizations. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.
1 . Conte C, Lee R, Sarkar M, Terman D (2018) A mathematical model of recurrent spreading depolarizations. J Comput Neurosci 44:203-217 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Extracellular; Glia; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Astrocyte;
Channel(s): I K; I Na,p; I Cl, leak; Na/K pump; Na+-glutamate transporter;
Gap Junctions:
Receptor(s): Glutamate;
Transmitter(s): Glutamate;
Simulation Environment: XPP;
Model Concept(s): Detailed Neuronal Models; Potassium buffering; Spreading depression; Spreading depolarization;
Implementer(s): Terman, David [terman at math.ohio-state.edu];
Search NeuronDB for information about:  Glutamate; I Na,p; I K; Na/K pump; I Cl, leak; Na+-glutamate transporter; Glutamate;
File not selected

<- Select file from this column.
Loading data, please wait...