Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Accession:
235768
" ...Loss of tonic neuromodulatory excitation, mediated by nicotinic acetylcholine or serotonin (5HT3A) receptors, of 5HT3-immunopositive interneurons caused an increase in amplitude and slowing of the delta rhythm until each period became the "wave" component of the spike and wave discharge. As with the normal delta rhythm, the wave of a spike and wave discharge originated in cortical layer 5. In contrast, the "spike" component of the spike and wave discharge originated from a relative failure of fast inhibition in layers 2/3-switching pyramidal cell action potential outputs from single, sparse spiking during delta rhythms to brief, intense burst spiking, phase-locked to the field spike. The mechanisms underlying this loss of superficial layer fast inhibition, and a concomitant increase in slow inhibition, appeared to be precipitated by a loss of neuropeptide Y (NPY)-mediated local circuit inhibition and a subsequent increase in vasoactive intestinal peptide (VIP)-mediated disinhibition. Blockade of NPY Y1 receptors was sufficient to generate spike and wave discharges, whereas blockade of VIP receptors almost completely abolished this form of epileptiform activity. These data suggest that aberrant, activity-dependent neuropeptide corelease can have catastrophic effects on neocortical dynamics."
Reference:
1 .
Hall S, Hunt M, Simon A, Cunnington LG, Carracedo LM, Schofield IS, Forsyth R, Traub RD, Whittington MA (2015) Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity.
J Neurosci
35
:9302-14
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
FORTRAN;
Model Concept(s):
Epilepsy;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
/
HallEtAl2015
readme.html
dexptablebig_setup.f
*
Other models using dexptablebig_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
dexptablesmall_setup.f
*
Other models using dexptablesmall_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
fnmda.f
*
Other models using fnmda.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
groucho_gapbld.f
*
Other models using groucho_gapbld.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
groucho_gapbld_mix.f
*
Other models using groucho_gapbld_mix.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_deepaxaxx.f
*
Other models using integrate_deepaxaxx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_deepbaskx.f
*
Other models using integrate_deepbaskx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_deepLTSx.f
*
Other models using integrate_deepLTSx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_deepng.f
*
Other models using integrate_deepng.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_nontuftRSXXB.f
*
Other models using integrate_nontuftRSXXB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_nrtxB.f
*
Other models using integrate_nrtxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_spinstelldiegoxB.f
*
Other models using integrate_spinstelldiegoxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_supaxaxx.f
*
Other models using integrate_supaxaxx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_supbaskx.f
*
Other models using integrate_supbaskx.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_supLTSX.f
*
Other models using integrate_supLTSX.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_supng.f
*
Other models using integrate_supng.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_suppyrFRBxPB.f
*
Other models using integrate_suppyrFRBxPB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_suppyrRS.f
*
Other models using integrate_suppyrRS.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_suppyrRS[1].f
*
Other models using integrate_suppyrRS[1].f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
integrate_suppyrRSXPB.f
*
Other models using integrate_suppyrRSXPB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_tcrxB.f
*
Other models using integrate_tcrxB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_tuftIBVx3B.f
*
Other models using integrate_tuftIBVx3B.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
integrate_tuftRSXXB.f
*
Other models using integrate_tuftRSXXB.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
makefile
*
Other models using makefile:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
otis_table_setup.f
*
Other models using otis_table_setup.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
spikewaveS1.pdf
spikewaveS1.png
spikewaveS5.f
*
Other models using spikewaveS5.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
spikewaveS5.pdf
spikewaveS5.png
synaptic_compmap_construct.f
*
Other models using synaptic_compmap_construct.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
synaptic_map_construct.f
*
Other models using synaptic_map_construct.f:
Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
The origin of different spike and wave-like events (Hall et al 2017)
File not selected
<- Select file from this column.
Loading data, please wait...
