Fast Spiking Basket cells (Tzilivaki et al 2019)

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Accession:237595
"Interneurons are critical for the proper functioning of neural circuits. While often morphologically complex, dendritic integration and its role in neuronal output have been ignored for decades, treating interneurons as linear point neurons. Exciting new findings suggest that interneuron dendrites support complex, nonlinear computations: sublinear integration of EPSPs in the cerebellum, coupled to supralinear calcium accumulations and supralinear voltage integration in the hippocampus. These findings challenge the point neuron dogma and call for a new theory of interneuron arithmetic. Using detailed, biophysically constrained models, we predict that dendrites of FS basket cells in both hippocampus and mPFC come in two flavors: supralinear, supporting local sodium spikes within large-volume branches and sublinear, in small-volume branches. Synaptic activation of varying sets of these dendrites leads to somatic firing variability that cannot be explained by the point neuron reduction. Instead, a 2-stage Artificial Neural Network (ANN), with both sub- and supralinear hidden nodes, captures most of the variance. We propose that FS basket cells have substantially expanded computational capabilities sub-served by their non-linear dendrites and act as a 2-layer ANN."
Reference:
1 . Tzilivaki A, Kastellakis G, Poirazi P (2019) Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators Nature Communications 10(1):3664 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Prefrontal cortex (PFC);
Cell Type(s): Hippocampus CA3 interneuron basket GABA cell; Neocortex layer 5 interneuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models;
Implementer(s): Tzilivaki, Alexandra [alexandra.tzilivaki at charite.de]; Kastellakis, George [gkastel at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 interneuron basket GABA cell;
	//Template for the detailed  FS Somogyi_23!
	//Alexandra Tzilivaki  


	begintemplate FScell 
	external v_init
	objref unscrProx, unscrDist
	objref all, somatic, axonal, basal_prox, basal_dist
	//Public members need to be declared afterwards:
	public soma, axon, dend 
	public init //enables the init() to be called again after object is created!
	public all, somatic, axonal, basal_prox, basal_dist
	public dendproxNo, denddistNo
	public unscrProx, unscrDist
	//Initial creation necessary (segmentation violation error otherwise):
	create soma, axon, dend


	proc init () {
		print "Opening gjhui",  $s1
	//The right amount of compartments is declared per object instance inside
	//the loaded morphology script:
		xopen($s1) // !! 

		dendproxNo=0
		denddistNo=0
	//Create public members for the number of proximal (distal) dendrites,
	//accessible through dot notation (i.e. myFS.dendproxNo):
		forsec basal_prox dendproxNo = dendproxNo + 1
		forsec basal_dist denddistNo = denddistNo + 1

	//Define electrophysiological properties:
		//..........................................................................................................................................................................
		soma_Nafin= 0.045/*//*0.025//0.060*3*/                                      
		soma_kdrin=0.018*2//*0.028//0.0018*2
		soma_Kslowin=0.000725/*//*0.1//*0.00006*0.1//0.000725*0.1 //*0.1 9/12/15*/
		soma_hin=0.00001/*//*10//*100//*100//*100//*/                                                    
		soma_kapin=0.0032//*2//*0.1//*2//*0.001
		soma_can=0.0003//*2 alexandra 17/12/2015
		soma_cat=0.001*2 //for dends
		soma_kctin=0.0001//*10//100//*100//*10                   
		soma_kcain=20*0.001//..001//0.5//*0   
		               
		//...........................................................................................................................................................................

		forsec somatic {
		
		        nseg= 5 //1 12/16
			insert pas
			cm=1.2//microF/cm2
			g_pas =1/7600                               
			e_pas = v_init
			Ra=172 //(Noerenberg et al, 2010 PNAS)

		insert Nafx
			gnafbar_Nafx= soma_Nafin*0.8*11

			insert kdrin
			gkdrbar_kdrin= soma_kdrin*1.2

			insert IKsin	
			gKsbar_IKsin= soma_Kslowin

			insert hin
			gbar_hin=soma_hin

			insert kapin
			gkabar_kapin=soma_kapin

			insert kctin
			gkcbar_kctin=soma_kctin

			insert kcain
			gbar_kcain=soma_kcain

		          
		         insert cadynin // cai

		}

			                
		forsec axonal {
		
		        nseg=10          
			insert pas
			cm=1.2
			g_pas =1/281600
			e_pas = v_init
			Ra=172

			insert Nafx
			gnafbar_Nafx=soma_Nafin*0.8*36
						                                                                    
			insert kdrin
			gkdrbar_kdrin=soma_kdrin*4

		}
		      
		forsec basal_prox {
		
		        nseg=5
			insert pas
			cm=1.2//microF/cm2
			g_pas =1/7600  
			e_pas = v_init                                            
			Ra=142

			insert Nafx
			gnafbar_Nafx=soma_Nafin*0.4//*0.8//*1.2

			insert kdrin
			gkdrbar_kdrin=0.018*0.5
                        
                        insert kapin
			gkabar_kapin=soma_kapin*0.2//*1.2                                                       

			insert can 
			gcabar_can = soma_can

			insert cat
			gcatbar_cat=soma_cat*0.1
		  
		        insert cal
		        gcalbar_cal=0.00003   // L type calcium channel

		        insert cadynin
		     
		}


		forsec basal_dist {
		
		        nseg=5
			insert pas
			cm=1.2           //microF/cm2
			g_pas =1/74300 
			e_pas = v_init                                            
			Ra=142

			insert Nafx
			gnafbar_Nafx=soma_Nafin*0.4*0.8//*0.8//*1.2

			insert kdrin
			gkdrbar_kdrin=0.018*0.5                                           
		        
                        insert kadin
                        gkabar_kadin=1.8*0.001      // IA current used in distal regions >100 microns from the soma
		       
            insert cat
			gcatbar_cat=soma_cat*0.1

			insert can
			gcabar_can=soma_can
		    
		        insert cal
		        gcalbar_cal=0.00003 
		          
		       insert cadynin
		       }	
	       
		ko0_k_ion = 3.82   //mM
		ki0_k_ion = 140    //mM  
	
	} //end init()

	endtemplate FScell



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