Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

 Download zip file 
Help downloading and running models
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
1 . Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell Reports 24(6):1536-1549 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): Ca pump; I K; I K,Ca; I Na,p; I h;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Synaptic Integration; Dendritic Action Potentials; Detailed Neuronal Models;
Implementer(s): Zang, Yunliang ;
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I K; I h; I K,Ca; Ca pump;
BK_Slow.mod *
CaP.mod *
capmax.mod *
CaT.mod *
cdp_AIS.mod *
cdp_smooth.mod *
cdp_soma.mod *
cdp_spiny.mod *
ih.mod *
Kv1.mod *
kv3.mod *
kv4f.mod *
kv4s.mod *
mslo.mod *
nap.mod *
narsg.mod *
peak.mod *
pkjlk.mod *
SK2.mod *
syn2.mod *
File not selected

<- Select file from this column.
Loading data, please wait...