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Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
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Accession:
243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 .
Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells
Cell Reports
24(6)
:1536-1549
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
Ca pump;
I K;
I K,Ca;
I Na,p;
I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Active Dendrites;
Synaptic Integration;
Dendritic Action Potentials;
Detailed Neuronal Models;
Implementer(s):
Zang, Yunliang ;
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
I Na,p
;
I K
;
I h
;
I K,Ca
;
Ca pump
;
/
purkinje_pub
mod
BK_Slow.mod
*
Other models using BK_Slow.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
CaP.mod
*
Other models using CaP.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
capmax.mod
*
Other models using capmax.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
CaT.mod
*
Other models using CaT.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
cdp_AIS.mod
*
Other models using cdp_AIS.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
cdp_smooth.mod
*
Other models using cdp_smooth.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
cdp_soma.mod
*
Other models using cdp_soma.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
cdp_spiny.mod
*
Other models using cdp_spiny.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
distr.mod
ih.mod
*
Other models using ih.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Kv1.mod
*
Other models using Kv1.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
kv3.mod
*
Other models using kv3.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
kv4f.mod
*
Other models using kv4f.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
kv4s.mod
*
Other models using kv4s.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
mslo.mod
*
Other models using mslo.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
nap.mod
*
Other models using nap.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
narsg.mod
*
Other models using narsg.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
peak.mod
*
Other models using peak.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
pkjlk.mod
*
Other models using pkjlk.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
SK2.mod
*
Other models using SK2.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
syn2.mod
*
Other models using syn2.mod:
Dendritica (Vetter et al 2001)
Dendritica (Vetter et al 2001)
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
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