ModelDB: Disentangling astroglial physiology with a realistic cell model in silico (Savtchenko et al 2018)

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Disentangling astroglial physiology with a realistic cell model in silico (Savtchenko et al 2018)

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Accession:243508

"Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. ..."
Reference:
1 . Savtchenko LP, Bard L, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA (2018) Disentangling astroglial physiology with a realistic cell model in silico. Nat Commun 9:3554 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Glia;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Astrocyte;
Channel(s):	I Calcium; I Potassium; Kir;
Gap Junctions:	Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	NEURON; MATLAB; C or C++ program;
Model Concept(s):	Calcium waves; Calcium dynamics; Potassium buffering; Volume transmission; Membrane Properties;
Implementer(s):	Savtchenko, Leonid P [leonid.savtchenko at ucl.ac.uk];

Search NeuronDB for information about: I Calcium; I Potassium; Kir; Glutamate;

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