"In cerebellar Purkinje neuron (PN) dendrites, the transient
depolarisation associated with a climbing fibre (CF) EPSP
activates voltage-gated Ca2+ channels (VGCCs), voltage-gated K+
channels (VGKCs) and Ca2+ activated SK and BK K+ channels. The
resulting membrane potential (Vm) and Ca2+ transients play a
fundamental role in dendritic integration and synaptic plasticity
of parallel fibre inputs. Here we report a detailed investigation
of the kinetics of dendritic Ca2+ and K+ channels activated by
CF-EPSPs, based on optical measurements of Vm and Ca2+ transients
and on a single-compartment NEURON model reproducing experimental
data.
... "
Reference:
1 .
Ait Ouares K, Filipis L, Tzilivaki A, Poirazi P, Canepari M (2019) Two Distinct Sets of Ca2+ and K+ Channels Are Activated at Different Membrane Potentials by the Climbing Fiber Synaptic Potential in Purkinje Neuron Dendrites. J Neurosci 39:1969-1981 [PubMed]
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