Conductance based model for short term plasticity at CA3-CA1 synapses (Mukunda & Narayanan 2017)

 Download zip file 
Help downloading and running models
Accession:244922
We develop a new biophysically rooted, physiologically constrained conductance-based synaptic model to mechanistically account for short-term facilitation and depression, respectively through residual calcium and transmitter depletion kinetics. The model exhibits different synaptic filtering profiles upon changing certain parameters in the base model. We show degenercy in achieving similar plasticity profiles with different presynaptic parameters. Finally, by virtually knocking out certain conductances, we show the differential contribution of conductances.
Reference:
1 . Mukunda CL, Narayanan R (2017) Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms. J Physiol 595:2611-2637 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I h; I K; I CAN;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Conductance distributions; Short-term Synaptic Plasticity; Calcium dynamics; Neurotransmitter dynamics;
Implementer(s): Mukunda, Chinmayee L [chinmayeelm at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; I K; I h; I CAN;
 
/
MukundaNarayanan2017
data
.gitkeep
                            
File not selected

<- Select file from this column.
Loading data, please wait...