CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2019
mechanisms
ANsyn.mod *
bgka.mod *
burststim2.mod *
cad.mod
cadyn.mod *
cadyn_new.mod
cagk.mod *
cal.mod *
calH.mod *
cancr.mod *
car.mod *
cat.mod *
ccanl.mod *
gskch.mod *
h.mod *
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod *
iccr.mod *
ichan2.mod *
ichan2aa.mod *
ichan2bc.mod *
ichan2bs.mod *
ichan2vip.mod *
Ih.mod *
Ihvip.mod *
ikscr.mod *
kad.mod *
kadistcr.mod *
kap.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
kdrcr.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nafcr.mod *
nap.mod *
Nasoma.mod *
nca.mod *
nmda.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
vecstim.mod *
                            
:  iC   fast Ca2+/V-dependent K+ channel

NEURON {
	SUFFIX iCcr
	USEION k READ ki, ko WRITE ik
	USEION ca READ cai
    RANGE ik, gk, gkcbar
}

UNITS {
    (mM) = (milli/liter)
	(mA) = (milliamp)
	(mV) = (millivolt)
	
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
	v		(mV)
	dt      (ms)
	cai		(mM)
	gkcbar= 0.0022	(mho/cm2)
  
}


STATE {
	c
}

ASSIGNED {
	ik (mA/cm2)
	cinf 
	ctau (ms)
	gk (mho/cm2)
	ek (mV)
	ki (mM)
	ko (mM)

}


INITIAL {
	rate()
	c = cinf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	gk = gkcbar*c*c
	ek = 25 * log(ko/ki)        
	ik = gk*(v-ek)
}



DERIVATIVE states {
    rate()
	c' = (cinf-c)/ctau
}

UNITSOFF


FUNCTION calf(v (mV), cai (mM)) (/ms) { LOCAL vs, va

       vs=v+40*log10(1000*cai)  :1000*cai
	   va=vs+18
	   if (fabs(va)<1e-04){  va=va+0.0001 }
	   calf = (-0.00642*vs-0.1152)/(-1+exp(-va/12))
}



FUNCTION cbet(v (mV), cai (mM))(/ms) { LOCAL vs, vb 

  vs=v+40*log10(cai*1000)
  vb=vs+152
  if (fabs(vb)<1e-04){ vb=vb+0.0001 }
  cbet = 1.7*exp(-vb/30)

}	



UNITSON

PROCEDURE rate() {LOCAL  csum, ca, cb

	ca=calf(v, cai) cb=cbet(v, cai)
		
	csum = ca+cb
	cinf = ca/csum
	if ((1/csum)>1.1) { ctau = 1 / csum}
	else { ctau = 1.1 }
		
}
	






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