CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2019
mechanisms
ANsyn.mod *
bgka.mod *
burststim2.mod *
cad.mod
cadyn.mod *
cadyn_new.mod
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cancr.mod *
car.mod *
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ccanl.mod *
gskch.mod *
h.mod *
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hNa.mod *
IA.mod *
iccr.mod *
ichan2.mod *
ichan2aa.mod *
ichan2bc.mod *
ichan2bs.mod *
ichan2vip.mod *
Ih.mod *
Ihvip.mod *
ikscr.mod *
kad.mod *
kadistcr.mod *
kap.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
kdrcr.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
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nafcr.mod *
nap.mod *
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nca.mod *
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regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
vecstim.mod *
                            
TITLE K-A channel from Klee Ficker and Heinemann
: modified to account for Dax A Current ----------
: M.Migliore Jun 1997
: modified by Poirazi on 10/2/00 according to Hoffman_etal97 
: to account for I_A proximal (<100microns)
: (n) activation, (l) inactivation


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
    dt (ms)
    v (mV)
    ek (mV)              : must be explicitely def. in hoc
    gkabar=.007 (mho/cm2)
    vhalfn= 11   (mV)
    vhalfl=-56   (mV)
    a0l=0.05      (/ms)
    a0n=0.05    (/ms)
}

NEURON {
	SUFFIX kap
	USEION k READ ek WRITE ik
    RANGE gkabar,gka
    GLOBAL ninf,linf,taul,taun
}

STATE {
	n
    l
}

ASSIGNED {
	ik (mA/cm2)
    ninf
    linf
    taul
    taun
    gka
}

INITIAL {
	rates(v)
	n=ninf
	l=linf
	gka = gkabar*n^4*l
	ik = gka*(v-ek)
}

BREAKPOINT {
	SOLVE states
	gka = gkabar*n^4*l
	ik = gka*(v-ek)
}

FUNCTION alpn(v(mV)) {
  alpn = -0.01*(v+21.3)/(exp((v+21.3)/-35)-1)
}


FUNCTION betn(v(mV)) {
  betn = 0.01*(v+21.3)/(exp((v+21.3)/35)-1)
}

FUNCTION alpl(v(mV)) {
  alpl = -0.01*(v+58)/(exp((v+58)/8.2)-1)
}

FUNCTION betl(v(mV)) {
  betl = 0.01*(v+58)/(exp((v+58)/-8.2)-1)
}

LOCAL facn,facl
PROCEDURE states() {     : exact when v held constant; integrates over dt step
    rates(v)
    n = n + facn*(ninf - n)
    l = l + facl*(linf - l)
    VERBATIM
    return 0;
    ENDVERBATIM
}

PROCEDURE rates(v (mV)) { :callable from hoc
    LOCAL a,b
    a = alpn(v)
    b = betn(v)
    ninf = a/(a + b)
    taun = 0.2
    facn = (1 - exp(-dt/taun))
    a = alpl(v)
    b = betl(v)
    linf = a/(a + b)
    
    if (v > -20) {
   taul = 5 + 2.6*(v+20)/10
    } else {
   taul = 5
    }
    facl = (1 - exp(-dt/taul))
}

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