Factors contribution to GDP-induced [Cl-]i transients (Lombardi et al 2019)

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Accession:253369
This models are used to evaluate which factors influence the GDP (giant depolarizing potential) induced [Cl-]I transients based on a initial model of P. Jedlicka
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2019) Interactions Between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl-Transport Shape Activity-Dependent Changes of Intracellular Cl- Concentration Int J of Mol Sci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite; Synapse;
Brain Region(s)/Organism: Mouse; Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; Gaba;
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LombardiEtAl2019
Real_Cell_Cl_HCO3_1GDP_Var-Cl-gGABA__Fig3
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
VDpas.mod *
vecevent.mod *
Cell1_Cl_HCO3_VDPas.hoc *
GDP_Cl_HCO3_All_short.ses *
Single_GDP_gGABA789_VDpas_Div_nGABA-1505_Div_Cl.hoc
Single_GDP_gGABA789_VDpas_Div_nGABA-301_Div_Cl.hoc
Single_GDP_gGABA789_VDpas_Div_nGABA-3010_Div_Cl.hoc
Single_GDP_gGABA789_VDpas_Div_nGABA-602_Div_Cl.hoc
Single_GDP_gGABA789_VDpas_Div_nGABA-6020_Div_Cl.hoc
Single_GDP_nGABA-302_VDpas_Div_gGABA_Div_Cl.hoc
start_Single_GDP_gGABA789_VDpas_Div_nGABA-1505_Div_Cl.hoc
start_Single_GDP_gGABA789_VDpas_Div_nGABA-301_Div_Cl.hoc
start_Single_GDP_gGABA789_VDpas_Div_nGABA-3010_Div_Cl.hoc
start_Single_GDP_gGABA789_VDpas_Div_nGABA-602_Div_Cl.hoc
start_Single_GDP_gGABA789_VDpas_Div_nGABA-6020_Div_Cl.hoc
start_Single_GDP_nGABA-302_VDpas_Div_gGABA_Div_Cl.hoc
                            
:  Vector stream of events

NEURON {
	THREADSAFE
	ARTIFICIAL_CELL VecStim
	POINTER ptr
}

ASSIGNED {
	index
	etime (ms)
	ptr
}


INITIAL {
	index = 0
	element()
	if (index > 0) {
		net_send(etime - t, 1)
	}
}

NET_RECEIVE (w) {
	if (flag == 1) {
		net_event(t)
		element()
		if (index > 0) {
			net_send(etime - t, 1)
		}
	}
}

DESTRUCTOR {
VERBATIM
	void* vv = (void*)(_p_ptr);
        if (vv) {
		hoc_obj_unref(*vector_pobj(vv));
	}
ENDVERBATIM
}

PROCEDURE element() {
VERBATIM
  { void* vv; int i, size; double* px;
	i = (int)index;
	if (i >= 0) {
		vv = (void*)(_p_ptr);
		if (vv) {
			size = vector_capacity(vv);
			px = vector_vec(vv);
			if (i < size) {
				etime = px[i];
				index += 1.;
			}else{
				index = -1.;
			}
		}else{
			index = -1.;
		}
	}
  }
ENDVERBATIM
}

PROCEDURE play() {
VERBATIM
	void** pv;
	void* ptmp = NULL;
	if (ifarg(1)) {
		ptmp = vector_arg(1);
		hoc_obj_ref(*vector_pobj(ptmp));
	}
	pv = (void**)(&_p_ptr);
	if (*pv) {
		hoc_obj_unref(*vector_pobj(*pv));
	}
	*pv = ptmp;
ENDVERBATIM
}

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