ModelDB: Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation (Luque et al 2019)

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Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation (Luque et al 2019)

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Accession:256140

"Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. ..."
Reference:
1 . Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS Comput Biol 15:e1006298 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism:	Cerebellum;
Cell Type(s):	Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; Vestibular neuron; Abstract integrate-and-fire leaky neuron;
Channel(s):	I K; I Na,t; I L high threshold; I M;
Gap Junctions:
Receptor(s):	AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:	EDLUT; NEURON; MATLAB;
Model Concept(s):	Activity Patterns; Sleep; Long-term Synaptic Plasticity; Vestibular;
Implementer(s):	Luque, Niceto R. [nluque at ugr.es];