Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation (Luque et al 2019)

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"Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. ..."
1 . Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS Comput Biol 15:e1006298 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; Vestibular neuron; Abstract integrate-and-fire leaky neuron;
Channel(s): I K; I Na,t; I L high threshold; I M;
Gap Junctions:
Receptor(s): AMPA; Gaba;
Simulation Environment: EDLUT; NEURON; MATLAB;
Model Concept(s): Activity Patterns; Sleep; Long-term Synaptic Plasticity; Vestibular;
Implementer(s): Luque, Niceto R. [nluque at ugr.es];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; AMPA; Gaba; I Na,t; I L high threshold; I K; I M;
Articulo purkinje
EDLUTKernel.cpp *
EDLUTMatlab.cpp *
EDLUTSfunction.cpp *
Feedback_control_loop_VOR.cpp *
PrecisionTest.cpp *
RealTimeEDLUTKernel.cpp *
SimulatedRobotControl.cpp *
SimulatedRobotControl3Joint.cpp *
SimulatedRobotControl3JointPrueba2.cpp *
StepByStep.cpp *
 *                           StepByStep.cpp                                *
 *                           -------------------                           *
 * copyright            : (C) 2010 by Jesus Garrido                        *
 * email                : jgarrido@atc.ugr.es                              *

 *                                                                         *
 *   This program is free software; you can redistribute it and/or modify  *
 *   it under the terms of the GNU General Public License as published by  *
 *   the Free Software Foundation; either version 3 of the License, or     *
 *   (at your option) any later version.                                   *
 *                                                                         *

#include <cstdlib>
#include <cstdio>
#include <cstring>
#include <time.h>
#include <math.h> // TODO: maybe remove this

#include <iostream>

#include "../include/simulation/Simulation.h"
#include "../include/communication/ArrayInputSpikeDriver.h"
#include "../include/communication/ArrayOutputSpikeDriver.h"
#include "../include/communication/FileOutputSpikeDriver.h"
#include "../include/communication/FileOutputWeightDriver.h"

#include "../include/spike/EDLUTFileException.h"
#include "../include/spike/EDLUTException.h"

using namespace std;

 * \note This software is only an example of how to run step-by-step simulations.
 * This simulation runs with a 10-ms step and generates 10 random spikes each step 
 * in input cells.
int main(int ac, char *av[]) {
	int result = 0;
	clock_t startt, endt;
	const char * NetworkFile = "NET_EDLUT_wght_end_1_0.20_0.01_clsdlp.dat";
	const char * WeightsFile = "WGH_EDLUT_wght_end_1_0.20_0.01.dat";
	const char * LogFile = "LogActivity.dat";
	const char * FinalWeightFile = "FinalWeights.dat";

	bool SaveFinalWeights = true; // True -> Save weight at the end of the simulation. False -> Do not save weights at the end.
	float SavingWeightPeriod = 0; // Time period between sucessive saving of the weights. 0 -> Not save periodically.

	double SimulationTime = 1;
	double StepTime = 0.10;

	const int NumberInputCells = 42;

	// Create the new simulation object (and load the network and weight definition file)
	Simulation * Simul = new Simulation(NetworkFile,WeightsFile, SimulationTime);
	// Create a new input object to add input spikes
	ArrayInputSpikeDriver * InputDriver = new ArrayInputSpikeDriver();
	// Create a new output object to get output spikes
	ArrayOutputSpikeDriver * OutputDriver = new ArrayOutputSpikeDriver();

	// Create a new monitor driver object to record the network activity
	FileOutputSpikeDriver * MonitorDriver = new FileOutputSpikeDriver (LogFile,false);
	// Create a new weight driver object to record the weights
	FileOutputWeightDriver * WeightDriver = new FileOutputWeightDriver(FinalWeightFile);
	if (SavingWeightPeriod>0){
	// Get the external initial inputs (none in this simulation)

	startt = clock();					// Simulate network and catch errors
	double InputSpikeTimes [NumberInputCells];
	long int InputSpikeCells [NumberInputCells];

	double * OutputSpikeTimes;
	long int * OutputSpikeCells;
	// Simulate step by step.
	for (double CurrentTime = 0; CurrentTime<SimulationTime; CurrentTime+=StepTime){
		cout << "Simulation at time " << CurrentTime << endl;

		// Generate input spikes (we generate one spike at random time for each input cell)
		for (int i=0; i<NumberInputCells; ++i){
			InputSpikeTimes[i] = rand()*StepTime/RAND_MAX+CurrentTime;
			InputSpikeCells[i] = i;
		// Load inputs
		// Simulate until CurrentTime+StepTime

		// Get outputs and print them
		int OutputNumber = OutputDriver->GetBufferedSpikes(OutputSpikeTimes,OutputSpikeCells);

		if (OutputNumber>0){
			for (int i=0; i< OutputNumber; ++i){
				cout << "Output spike at time " << OutputSpikeTimes[i] << " from cell " << OutputSpikeCells[i] << endl;

			delete [] OutputSpikeTimes;
			delete [] OutputSpikeCells;
	endt = clock();

	// Final weight saving.

	cout << "Oky doky" << endl;

	cout << "Elapsed time: " << (endt-startt)/(float)CLOCKS_PER_SEC << " sec" << endl;
	for(int i=0; i<Simul.GetNumberOfQueues(); i++){
		cout << "Thread "<<i<<"--> Number of updates: " << Simul.GetSimulationUpdates(i) << endl; /*asdfgf*/
		cout << "Thread "<<i<<"--> Number of InternalSpike: " << Simul.GetTotalSpikeCounter(i) << endl; /*asdfgf*/
		cout << "Thread "<<i<<"--> Number of Propagated Spikes and Events: " << Simul.GetTotalPropagateCounter(i)<<", "<< Simul.GetTotalPropagateEventCounter(i)<< endl; /*asdfgf*/
		cout << "Thread "<<i<<"--> Mean number of spikes in heap: " << Simul.GetHeapAcumSize(i)/(float)Simul.GetSimulationUpdates(i) << endl; /*asdfgf*/
		cout << "Thread "<<i<<"--> Updates per second: " << Simul.GetSimulationUpdates(i)/((endt-startt)/(float)CLOCKS_PER_SEC) << endl; /*asdfgf*/
	cout << "Total InternalSpike: " << Simul.GetTotalSpikeCounter()<<endl; 
	cout << "Total Propagated Spikes and Events: " << Simul.GetTotalPropagateCounter()<<", "<< Simul.GetTotalPropagateEventCounter()<<endl;

	// Closing simulation connections
	delete Simul;
	delete InputDriver;
	delete OutputDriver;
	delete MonitorDriver;
	delete WeightDriver;

	return result;

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