DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)

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We present computational models for an Abeta-LTMR (low-threshold mechanoreceptor) and a C-LTMR expressing four Na channels and four K channels to investigate how the expression level of Kv1 and Kv4 regulate number of spikes (repetitive firing) and onset latency to action potentials in Abeta-LTMRs and C-LTMRs, respectively.
1 . Zheng Y, Liu P, Bai L, Trimmer JS, Bean BP, Ginty DD (2019) Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties Neuron
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Mouse;
Cell Type(s): Dorsal Root Ganglion (DRG) cell;
Channel(s): I Sodium; I Potassium; I K; I A;
Gap Junctions:
Gene(s): Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv2.1 KCNB1; Kv3.1 KCNC1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.3 KCND3;
Simulation Environment: NEURON; R;
Model Concept(s): Action Potential Initiation; Action Potentials; Activity Patterns; Delay; Ion Channel Kinetics; Membrane Properties;
Implementer(s): Zheng, Yang [zylittlep at gmail.com]; Bean, Bruce [bruce_bean at hms.harvard.edu];
Search NeuronDB for information about:  I A; I K; I Sodium; I Potassium;
proc set_AbLTMR(){     
    soma.L = 30.90
    soma.diam = 30.90   
    gnabar_nav1p1 = 0.008
    gnabar_nav1p6 = 0.04
    gnabar_nav1p7 = 0.005
    gnabar_nav1p8 = 0
    gkbar_kv1 = 0.006
    gkbar_kv2 = 0.012
    gkbar_kv3 = 0.004
    gkbar_kv4 = 0.0008
    g_leak = 0.0001

proc set_CLTMR(){
    soma.L = 19.55
    soma.diam = 19.55
    gnabar_nav1p1 = 0
    gnabar_nav1p6 = 0
    gnabar_nav1p7 = 0.03
    gnabar_nav1p8 = 0.04
    gkbar_kv1 = 0.00006
    gkbar_kv2 = 0.002
    gkbar_kv3 = 0.00005
    gkbar_kv4 = 0.011
    g_leak = 0.00002

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