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Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
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Model Information
Model File
Citations
Accession:
257027
Most animal species operate according to a 24-hour period set by the suprachiasmatic nucleus (SCN) of the hypothalamus. The rhythmic activity of the SCN modulates hippocampal-dependent memory, but the molecular and cellular mechanisms that account for this effect remain largely unknown. In McCauley et al. 2020 [1], we identify cell-type specific structural and functional changes that occur with circadian rhythmicity in neurons and astrocytes in hippocampal area CA1. Pyramidal neurons change the surface expression of NMDA receptors. Astrocytes change their proximity clustered excitatory synaptic inputs, ultimately shaping hippocampal-dependent learning in vivo. We identify to synapses. Together, these phenomena alter glutamate clearance, receptor activation and integration of temporally corticosterone as a key contributor to changes in synaptic strength. These findings highlight important mechanisms through which neurons and astrocytes modify the molecular composition and structure of the synaptic environment, contribute to the local storage of information in the hippocampus and alter the temporal dynamics of cognitive processing. [1] "Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1" by J.P. McCauley, M.A. Petroccione, L.Y. D’Brant, G.C. Todd, N. Affinnih, J.J. Wisnoski, S. Zahid, S. Shree, A.A. Sousa, R.M. De Guzman, R. Migliore, A. Brazhe, R.D. Leapman, A. Khmaladze, A. Semyanov, D.G. Zuloaga, M. Migliore and A. Scimemi. Cell Reports (2020), https://doi.org/10.1016/j.celrep.2020.108255
Reference:
1 .
McCauley JP, Petroccione MA, D'Brant LY, Todd GC, Affinnih N, Wisnoski JJ, Zahid S, Shree S, Sousa AA, De Guzman RM, Migliore R, Brazhe A, Leapman RD, Khmaladze A, Semyanov A, Zuloaga DG, Migliore M, Scimemi A (2020) Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1.
Cell Rep
33
:108255
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Synapse;
Channel/Receptor;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Astrocyte;
Channel(s):
I A;
I h;
I M;
I K;
I K,Ca;
Ca pump;
I Calcium;
I CAN;
I Na,t;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Synaptic Integration;
Synaptic Plasticity;
Detailed Neuronal Models;
Implementer(s):
Migliore, Rosanna [rosanna.migliore at cnr.it];
Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
NMDA
;
I Na,t
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I CAN
;
I Calcium
;
Ca pump
;
Glutamate
;
/
modelDB-Migliore-Scimemi-2020
morph
readme_file
readme.htm
cacumm.mod
*
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Channel density variability among CA1 neurons (Migliore et al. 2018)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
cagk.mod
*
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CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Neuronal dendrite calcium wave model (Neymotin et al, 2015)
cal2.mod
*
Other models using cal2.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
can2.mod
*
Other models using can2.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
cat.mod
*
Other models using cat.mod:
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
CA3 pyramidal neuron (Safiulina et al. 2010)
CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Firing patterns of CA3 hippocampal neurons (Soldado-Magraner et al. 2019)
h.mod
*
Other models using h.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
kadist.mod
*
Other models using kadist.mod:
A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
A model of unitary responses from A/C and PP synapses in CA3 pyramidal cells (Baker et al. 2010)
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Distinct current modules shape cellular dynamics in model neurons (Alturki et al 2016)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
kaprox.mod
*
Other models using kaprox.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Excitability of PFC Basal Dendrites (Acker and Antic 2009)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Sympathetic Preganglionic Neurone (Briant et al. 2014)
kca.mod
*
Other models using kca.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
kdrca1.mod
*
Other models using kdrca1.mod:
CA1 pyramidal neuron (Migliore et al 1999)
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
Channel density variability among CA1 neurons (Migliore et al. 2018)
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Effects of electric fields on cognitive functions (Migliore et al 2016)
Estimation and Production of Time Intervals (Migliore et al 2001)
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Functional impact of dendritic branch point morphology (Ferrante et al., 2013)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
Model of CA1 activity during working memory task (Spera et al. 2016)
Modulation of hippocampal rhythms by electric fields and network topology (Berzhanskaya et al. 2013)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Vomeronasal sensory neuron (Shimazaki et al 2006)
kmb.mod
*
Other models using kmb.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)
ltpltd.mod
*
Other models using ltpltd.mod:
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
naxn.mod
*
Other models using naxn.mod:
Channel density variability among CA1 neurons (Migliore et al. 2018)
netstims.mod
*
Other models using netstims.mod:
CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
Early-onset epileptic encephalopathy (Miceli et al. 2015)
Effect of the initial synaptic state on the probability to induce LTP and LTD (Migliore et al. 2015)
Model of CA1 activity during working memory task (Spera et al. 2016)
Neural Query System NQS Data-Mining From Within the NEURON Simulator (Lytton 2006)
Neuronal morphology goes digital ... (Parekh & Ascoli 2013)
Optimal balance predicts/explains amplitude and decay time of iPSGs (Kim & Fiorillo 2017)
STDP and BDNF in CA1 spines (Solinas et al. 2019)
Superior paraolivary nucleus neuron (Kopp-Scheinpflug et al. 2011)
nmdanet.mod
tmgsynday.mod
cell_seed6_0_mouse1-AS.hoc
fig6C.hoc
mosinit.hoc
sim-day.ses
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