Hippocampus CA1 Interneuron Specific 3 (IS3) in vivo-like virtual NN simulations (Luo et al 2020)

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Accession:265523
"Disinhibition is a widespread circuit mechanism for information selection and transfer. In the hippocampus, disinhibition of principal cells is provided by the interneuron-specific interneurons that express the vasoactive intestinal polypeptide (VIP-IS) and innervate selectively inhibitory interneurons. By combining optophysiological experiments with computational models, we determined the impact of synaptic inputs onto the network state-dependent recruitment of VIP-IS cells. We found that VIP-IS cells fire spikes in response to both the Schaffer collateral and the temporoammonic pathway activation. Moreover, by integrating their intrinsic and synaptic properties into computational models, we predicted recruitment of these cells between the rising phase and peak of theta oscillation and during ripples. Two-photon Ca2+-imaging in awake mice supported in part the theoretical predictions, revealing a significant speed modulation of VIP-IS cells and their preferential albeit delayed recruitment during theta-run epochs, with estimated firing at the rising phase and peak of the theta cycle. However, it also uncovered that VIP-IS cells are not activated during ripples. Thus, given the preferential theta-modulated firing of VIP-IS cells in awake hippocampus, we postulate that these cells may be important for information gating during spatial navigation and memory encoding."
Reference:
1 . Luo X, Guet-McCreight A, Villette V, Francavilla R, Marino B, Chamberland S, Skinner FK, Topolnik L (2020) Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus. Cereb Cortex [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampal CA1 CR/VIP cell;
Channel(s): I Na,t; I Na,p; I A;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Spatial Navigation; Oscillations; Activity Patterns;
Implementer(s): Guet-McCreight, Alexandre [alexandre.guet.mccreight at mail.utoronto.ca];
Search NeuronDB for information about:  I Na,p; I Na,t; I A; Gaba; Glutamate;
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LuoEtAl2020Code
Theta_NoiseTests
SDprox2
NPYfiles
PLOTfiles
IKa.mod *
ingauss.mod *
Ksoma.mod *
Nap.mod *
Nasoma.mod *
vecevent.mod *
init.py *
IS3_M2_Case9StarRevised.hoc *
model_decaytimeinhvec.dat *
model_decaytimevec.dat *
model_dendsectionvec.dat *
model_distvec.dat *
model_minweightinhvec.dat *
model_minweightvec.dat *
model_risetimeinhvec.dat *
model_risetimevec.dat *
PlotResults.py
ranstream.hoc *
SynParamSearch.hoc
vecevent.hoc *
vecevent.ses *
                            
TITLE KA
: K-A current for hippocampal interneurons from Lien et al (2002)
: M.Migliore Jan. 2003

UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}

NEURON {
	THREADSAFE
	SUFFIX Ika
	USEION k READ ek WRITE ik
	RANGE  gbar, ik
	GLOBAL minf, hinf, htau, mtau
}

PARAMETER {
	gbar = 0.0002   (mho/cm2)
	celsius		(degC)
	ek		(mV)            : must be explicitly def. in hoc
	v 		(mV)
	a0h=0.17
	vhalfh=-105	(mV)
	q10=3
	hmin=5		(ms)
}

ASSIGNED {
	ik 	(mA/cm2)
	minf 		
	mtau 	(ms)
	hinf	 	
	htau 	(ms)
	
}
 
INITIAL {
        trates(v)
        m=minf
        h=hinf
}

STATE {m h}

BREAKPOINT {
        SOLVE state METHOD cnexp
	ik = gbar*m*h*(v - ek)
} 

DERIVATIVE state {   
        trates(v)      
        m' = (minf-m)/mtau
        h' = (hinf-h)/htau
}

PROCEDURE trates(v(mV)) {  
	LOCAL qt
        qt=q10^((celsius-23(degC))/10(degC))
        minf = (1/(1 + exp(-(v+41.4(mV))/26.6(mV))))^4
	mtau=0.5(ms)/qt
        hinf = 1/(1 + exp((v+78.5(mV))/6(mV)))
	htau = a0h*1(ms/mV)*(v-vhalfh)/qt
	if (htau<hmin/qt) {htau=hmin/qt}
}


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