Dynamical assessment of ion channels during in vivo-like states (Guet-McCreight & Skinner 2020)

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" ... Methods: We employ two morphologically-detailed multi-compartment models of a specific type of inhibitory interneuron, the oriens lacunosum moleculare (OLM) cell. The OLM cell is a well-studied cell type in CA1 hippocampus that is important in gating sensory and contextual information. We create in vivo-like states for these cellular models by including levels of synaptic bombardment that would occur in vivo. Using visualization tools and analyses we assess the ion channel current contribution profile across the different somatic and dendritic compartments of the models. Results: We identify changes in dendritic excitability, ion channel current contributions and co-activation patterns between in vitro and in vivo-like states. Primarily, we find that the relative timing between ion channel currents are mostly invariant between states, but exhibit changes in magnitudes and decreased propagation across dendritic compartments. We also find enhanced dendritic hyperpolarization-activated cyclic nucleotide-gated channel (h-channel) activation during in vivo-like states, which suggests that dendritically located h-channels are functionally important in altering signal propagation in the behaving animal. ..."
1 . Guet-McCreight A, Skinner F (2020) Computationally going where experiments cannot: a dynamical assessment of dendritic ion channel currents during in vivo-like states [version 1; peer review: 1 approved, 1 approved with reservations] F1000Research
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I h; I Na,t; I K; I A; I L high threshold; I T low threshold; I K,Ca; I M;
Gap Junctions:
Simulation Environment: NEURON (web link to model);
Model Concept(s): Active Dendrites; Dendritic Action Potentials;
Search NeuronDB for information about:  I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca;
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