Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)

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Accession:266578
We used two-photon microscopy to study the role of ensembles of cerebellar molecular layer interneurons (MLIs) in a go-no go task where mice obtain a sugar water reward. In order to begin understanding the circuit basis of our findings in changes in lick behavior with chemogenetics in the go-no go associative learning olfactory discrimination task we generated a simple computational model of MLI interaction with PCs.
Reference:
1 . Ma M, Futia GL, De Souza FM, Ozbay BN, Llano I, Gibson EA, Restrepo D (2020) Molecular layer interneurons in the cerebellum encode for valence in associative learning Nature Communications, accepted
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum; Mouse;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Detailed Neuronal Models;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell; GabaA; AMPA; Gaba; Glutamate;
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MaEtAl2020
README.html
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//DEFINITION OF CELL TEMPLATE

begintemplate fibre

public Presynapse
public x,y,z
public StimTrigger

objref StimTrigger

public nclist
objectvar nclist  

//counting spikes
public spiketimes,spikecount
objref spiketimes,spikecount

public syn 
objectvar syn 

public voltagem
objref voltagem

public randomseed
public position

create Presynapse	//create compartment

proc init() {

x=$1
y=$2
z=$3

randomseed = $4 //Fabio´s Stuff

spiketimes=new Vector()
lastspikecount=0

voltagem=new Vector()


Presynapse {

 //initialise and clear the 3D information
 pt3dclear()
 pt3dadd(x,y,z,10)	//set position of cell
 pt3dadd(x,y,z+10,10)

 diam=1.0
 L=1

nseg=1
diam=10.0
L=5
Ra=123
insert hh	//Hodgkin-Huxley channels
gnabar=0.25
gl_hh=.0001666
el_hh=-60 
syn=new ExpSyn(0) //Adding synapse

 nclist=new List()
 StimTrigger=new NetStim(0.5) //Adding spike generator
 
// Setting the random seed for the Spike Generator
StimTrigger.seed(randomseed)



//counting spikes
//spikecount=new APCount(0.5)
//spikecount.thresh=-20
//spikecount.record(spiketimes)

//Saving Vm
//voltagem.record(&v(0.5))
}
}

//Fabio´s stuff
proc position() {local i
  access Presynapse 
for i = 0, n3d()-1 {
    pt3dchange(i, $1-x+x3d(i), $2-y+y3d(i), $3-z+z3d(i), diam3d(i))
  }
  x = $1  y = $2  z = $3
}


endtemplate fibre



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