Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)

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Accession:266578
We used two-photon microscopy to study the role of ensembles of cerebellar molecular layer interneurons (MLIs) in a go-no go task where mice obtain a sugar water reward. In order to begin understanding the circuit basis of our findings in changes in lick behavior with chemogenetics in the go-no go associative learning olfactory discrimination task we generated a simple computational model of MLI interaction with PCs.
Reference:
1 . Ma M, Futia GL, De Souza FM, Ozbay BN, Llano I, Gibson EA, Restrepo D (2020) Molecular layer interneurons in the cerebellum encode for valence in associative learning Nature Communications, accepted
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum; Mouse;
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Detailed Neuronal Models;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; Cerebellum interneuron stellate GABA cell; GabaA; AMPA; Gaba; Glutamate;
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MaEtAl2020
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TITLE GKCA
: FORREST MD (2014) Two Compartment Model of the Cerebellar Purkinje Neuron 

UNITS {
       (molar) = (1/liter)
        (pA) = (picoamp)
	(mV) =	(millivolt)
        (S) = (siemens)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
}


INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
	SUFFIX gkca
	USEION ca READ cai
	USEION k  WRITE ik
	RANGE  gkbar,km,oinf,n,ik
 
}


PARAMETER {
        dt (ms)
        cai   (mM)
        km = 0.00019    (mM)
        n = 4.0
        cainit = 0.000184 (mM)
        celsius = 35  (degC)
        gkbar = 0 (mho/cm2)        : (S/cm2)
 :       ek = -100 (mV)
        
 
}

ASSIGNED { 
           ik		(mA/cm2)
           oinf           
           ek (mV)
}


BREAKPOINT {
        oinf = 1/(1 + pow(km/cai,n))
	ik = oinf*gkbar*(v - ek)
}


COMMENT
INITIAL{
       cai = cainit}
ENDCOMMENT


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