Purkinje neuron network (Zang et al. 2020)

 Download zip file 
Help downloading and running models
Accession:266799
Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na+ channels. Then we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei.
Reference:
1 . Zang Y, Hong S, De Schutter E (2020) Firing rate-dependent phase responses of Purkinje cells support transient oscillations. Elife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Phase Response Curves; Action Potentials; Spatio-temporal Activity Patterns; Synchronization; Action Potential Initiation; Oscillations;
Implementer(s): Zang, Yunliang ; Hong, Sungho [shhong at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; 
-109	1
-107	0.999759
-105	0.999501
-103	0.999356
-101	0.999426
-99	0.99947
-97	0.999483
-95	0.999457
-93	0.999383
-91	0.999249
-89	0.999038
-87	0.99873
-85	0.998296
-83	0.997699
-81	0.996887
-79	0.995786
-77	0.994291
-75	0.992247
-73	0.989425
-71	0.985468
-69	0.97981
-67	0.971532
-65	0.959107
-63	0.939981
-61	0.90995
-59	0.862529
-57	0.789203
-55	0.682806
-53	0.545756
-51	0.397177
-49	0.265086
-47	0.167186
-45	0.10367
-43	0.0654958
-41	0.0432352
-39	0.0302952
-37	0.0226337
-35	0.0179421
-33	0.0149849
-31	0.013068
-29	0.0117936
-27	0.0109284
-25	0.0105329
-23	0.0102219
-21	0.0102879
-19	0.0106966
-17	0.0111358
-15	0.0116042
-13	0.0121003
-11	0.0126223

Loading data, please wait...