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Purkinje neuron network (Zang et al. 2020)
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Model Information
Model File
Citations
Accession:
266799
Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na+ channels. Then we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei.
Reference:
1 .
Zang Y, Hong S, De Schutter E (2020) Firing rate-dependent phase responses of Purkinje cells support transient oscillations.
Elife
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Realistic Network;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Model Concept(s):
Phase Response Curves;
Action Potentials;
Spatio-temporal Activity Patterns;
Synchronization;
Action Potential Initiation;
Oscillations;
Implementer(s):
Zang, Yunliang ;
Hong, Sungho [shhong at oist.jp];
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
/
PRC_network_code
figure2
figure2C
mod
abBK.mod
*
Other models using abBK.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
apthreshold.mod
*
Other models using apthreshold.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
CaP_Raman.mod
*
Other models using CaP_Raman.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp_spiny.mod
*
Other models using cdp_spiny.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp10AIS.mod
*
Other models using cdp10AIS.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp20N_FD2.mod
*
Other models using cdp20N_FD2.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp4N.mod
*
Other models using cdp4N.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
distr.mod
*
Other models using distr.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
ihnew.mod
*
Other models using ihnew.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
kv11.mod
*
Other models using kv11.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Kv1A.mod
*
Other models using Kv1A.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
kv3.mod
*
Other models using kv3.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
Kv34.mod
*
Other models using Kv34.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
kv4hybrid2.mod
*
Other models using kv4hybrid2.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
kv4s.mod
*
Other models using kv4s.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
mslo.mod
*
Other models using mslo.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
nap.mod
*
Other models using nap.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
peak.mod
*
Other models using peak.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
pkjlk.mod
*
Other models using pkjlk.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
rsgold.mod
SK2.mod
*
Other models using SK2.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
syn2.mod
*
Other models using syn2.mod:
Dendritica (Vetter et al 2001)
Dendritica (Vetter et al 2001)
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
TCa.mod
*
Other models using TCa.mod:
Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
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