Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)

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Accession:266806
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. To study the mechanisms through which these neurons integrate complex input patterns, a new set of models were developed using the latest experimental information and a genetic algorithm approach to fit the maximum ionic channel conductances. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons.
Reference:
1 . Masoli S, Ottaviani A, Casali S, D'Angelo E (2020) Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS Comput Biol 16:e1007937 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Neurotransmitter dynamics; Calcium dynamics;
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it];
Search NeuronDB for information about:  I Sodium;
0.00499506303209 0.01016375552607 0.00247172479141 0.00128859564935 3.690771983E-05 0.0080938853146 0.01226052748146 0.01650689958385 0.00139885617712 0.14927733727426 0.00549507510519 0.14910988921938 0.00406420380423 0.01764345789036 0.10177335775222 0.0087689418803 3.407734319E-05 0.0003371456442 0.00030643090764 0.17233663543619 0.00024381226198 0.10008178886943 0.00595046001148 0.0115 0.0091

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