ModelDB is moving. Check out our new site at https://modeldb.science. The corresponding page is https://modeldb.science/266806.

Cerebellar Golgi cells, dendritic processing, and synaptic plasticity (Masoli et al 2020)

 Download zip file 
Help downloading and running models
Accession:266806
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. To study the mechanisms through which these neurons integrate complex input patterns, a new set of models were developed using the latest experimental information and a genetic algorithm approach to fit the maximum ionic channel conductances. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons.
Reference:
1 . Masoli S, Ottaviani A, Casali S, D'Angelo E (2020) Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS Comput Biol 16:e1007937 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Neurotransmitter dynamics; Calcium dynamics;
Implementer(s): Masoli, Stefano [stefano.masoli at unipv.it];
Search NeuronDB for information about:  I Sodium;
/
Golgi_cell_2020
Morphology_1
mod_files
Cav12.mod *
Cav13.mod *
Cav2_3.mod *
Cav3_1.mod *
cdp5StCmod.mod *
GOLGI_Ampa_mossy_det_vi.mod *
GOLGI_Ampa_pf_aa_det_vi.mod *
GRC_CA.mod *
GRC_KM.mod *
Hcn1.mod *
Hcn2.mod *
Kca11.mod *
Kca22.mod *
Kca31.mod *
Kv11.mod *
Kv34.mod *
Kv43.mod *
Leak.mod *
Nav16.mod *
PC_NMDA_NR2B.mod *
                            
COMMENT

   **************************************************
   File generated by: neuroConstruct v1.3.7 
   **************************************************


ENDCOMMENT


: This is a NEURON mod file generated from a ChannelML file

:  Unit system of original ChannelML file: Physiological Units

COMMENT
    ChannelML file containing a single Channel description
ENDCOMMENT

TITLE Channel: Leak

COMMENT
    Simple example of a leak/passive conductance. Note: for GENESIS cells with a single leak conductance,
        it is better to use the Rm and Em variables for a passive current.
ENDCOMMENT


UNITS {
    (mA) = (milliamp)
    (mV) = (millivolt)
    (S) = (siemens)
    (um) = (micrometer)
    (molar) = (1/liter)
    (mM) = (millimolar)
    (l) = (liter)
}


    
NEURON {
      

    SUFFIX Leak
    : A non specific current is present
    RANGE e
    NONSPECIFIC_CURRENT il
    
    RANGE gmax, gion,il
    
}

PARAMETER { 
      

    gmax = 0.0003 (S/cm2) : default value, should be overwritten when conductance placed on cell
    
    e = -80 (mV) : default value, should be overwritten when conductance placed on cell
    
}



ASSIGNED {
      

    v (mV)
        
    il (mA/cm2)
        
}

BREAKPOINT { 
    il = gmax*(v - e) 
        

}



Loading data, please wait...