Fhf2WT and Fhf2KO mouse ventricular cardiomyocyte models differ only in the inactivation gating of voltage-gated sodium channels. Cardiomyocyte linear strands were constructed by electrically coupling 111 model cells. Action potential conduction through the Fhf2KO strand is blocked by a range of stressors, including temperature elevation or reduction in sodium, calcium, or gap junctional conductance densities. Conduction through the Fhf2WT model strand is resistant to these stresses.
Park DS, Shekhar A, Santucci Iii J, Redel-Traub G, Solinas SM, Mintz S, Lin X, Chang EW, Narke D, Xia Y, Goldfarb M, Fishman GI (2020) Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Circ Res [PubMed]