FHF2KO and Wild-Type Mouse Cardiomyocyte Strands (Park et al 2020)

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Accession:266818
Fhf2WT and Fhf2KO mouse ventricular cardiomyocyte models differ only in the inactivation gating of voltage-gated sodium channels. Cardiomyocyte linear strands were constructed by electrically coupling 111 model cells. Action potential conduction through the Fhf2KO strand is blocked by a range of stressors, including temperature elevation or reduction in sodium, calcium, or gap junctional conductance densities. Conduction through the Fhf2WT model strand is resistant to these stresses.
Reference:
1 . Park DS, Shekhar A, Santucci Iii J, Redel-Traub G, Solinas SM, Mintz S, Lin X, Chang EW, Narke D, Xia Y, Goldfarb M, Fishman GI (2020) Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Circ Res [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I K; Na/K pump; I L high threshold; I Na,t;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Conduction failure; Detailed Neuronal Models; Heart disease; Ion Channel Kinetics; Temperature;
Implementer(s): Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu]; Solinas, Sergio [solinas at unipv.it];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; Na/K pump;
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