Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Accession:266823
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons PLOS Comp Bio
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Synaptic Plasticity; Chloride regulation;
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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_For Zip -Neuron-Models_AMPA-GABA
Fig6de_Ball-stick_tonic_GABA
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
tonic.mod *
vecevent.mod *
cell_soma_dendrite_pas.hoc *
cell_soma_dendrite_tonicGABA.hoc
Determine_Rinput.ses
Determine_Rinput-Info.txt
Display_One_AMPA.ses
GABA-AMPA_BS-Effect-AMPA-on-tonic-GABA_Var-Cl_tauAMPA-hand.hoc
GABA-AMPA_BS-NOtonicGABA_Dif-gAMPA_Var-Cl.hoc
GABA-AMPA_BS-tonicGABA_Dif-gAMPA_Var-Cl.hoc
GABA-AMPA_BS-tonicGABA_One_AMPA.hoc
GABA-AMPA_BS-tonicGABA_var-temp_rel_AMPA_Var-Cl_tauGABA-hand_AMPA-hand.hoc
init_Cldif.hoc *
Isolated_Dendrite.ses *
start_GABA-AMPA_BS-NOtonicGABA_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-passive_No-synGABA_var-temp_rel_AMPA_Var-Cl_AMPA-hand.hoc
start_GABA-AMPA_BS-tonicGABA_Dif-gAMPA_Var-Cl.hoc
start_GABA-AMPA_BS-tonicGABA_No-synGABA_var-temp_rel_AMPA_Var-Cl_AMPA-hand.hoc
start_GABA-AMPA_BS-tonicGABA_One_AMPA.hoc
start_GABA-AMPA_BS-tonicGABA_var-temp_rel_AMPA_Var-Cl_tauGABA-hand_AMPA-hand.hoc
                            
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[4]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin I/V Clamp Electrode
{
load_file("electrod.hoc")
}
{
ocbox_=new Electrode(0)
execute("can_locate=1 sec=\"soma\" xloc=0.5 locate(0)", ocbox_)
execute("vc.dur[0]=0.1 vc.amp[0]=-65", ocbox_)
execute("vc.dur[1]=2.5 vc.amp[1]=10", ocbox_)
execute("vc.dur[2]=100 vc.amp[2]=-65", ocbox_)
execute("stim.del=10 stim.dur=100 stim.amp=-0.1", ocbox_)
execute("vcsteps=5", ocbox_)
execute("samp=stim.amp  store_vclamp() glyph()", ocbox_)
ocbox_ = ocbox_.v1
ocbox_.map("I/V Clamp Electrode", 2173, 555, 225, 365.4)
}
objref ocbox_
//End I/V Clamp Electrode

{
save_window_ = new Graph(0)
save_window_.size(0,100,-80,40)
scene_vector_[2] = save_window_
{save_window_.view(0, -80, 100, 120, 2839, 244, 495, 200.8)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{
xpanel("RunControl", 0)
v_init = -60
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 100
xvalue("t","t", 2 )
tstop = 100
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
screen_update_invl = 0.05
xvalue("Scrn update invl","screen_update_invl", 1,"", 0, 1 )
realtime = 0.05
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(2175,97)
}
objectvar scene_vector_[1]
{doNotify()}

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