Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Accession:266823
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons PLOS Comp Bio
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Synaptic Plasticity; Chloride regulation;
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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_For Zip -Neuron-Models_AMPA-GABA
Fig5_Ball-stick_temp-Rel
cldif_CA3_NKCC1_HCO3.mod *
gabaA_Cl_HCO3.mod *
vecevent.mod *
cell_soma_dendrite.hoc *
GABA-AMPA_BS_var-temp_rel_AMPA_Var-Cl.hoc
GABA-AMPA_BS_Var-temp_rel_AMPA_Var-Cl_essential_traces_high res.hoc
GABA-AMPA_BS_var-temp_rel_AMPA_Var-Cl_tauGABA-hand_AMPA-hand.hoc *
GABA-AMPA_BS_Var-temp_var-tauGABA_tauAMPA-37ms_Cli-25mM_long.hoc
GABA-AMPA_BS_Var-temp_var-tauGABA_tauAMPA-37ms_Cli-5mM_long.hoc
init_Cldif.hoc *
Isolated_Dendrite.ses *
start_GABA-AMPA_BS_var-temp_rel_AMPA_Var-Cl.hoc
start_GABA-AMPA_BS_Var-temp_rel_AMPA_Var-Cl_essential_traces_high res.hoc
start_GABA-AMPA_BS_var-temp_rel_AMPA_Var-Cl_tauGABA-hand_AMPA-hand.hoc
start_GABA-AMPA_BS_Var-temp_var-tauGABA_tauAMPA-37ms_Cli-25mM_long.hoc
start_GABA-AMPA_BS_Var-temp_var-tauGABA_tauAMPA-37ms_Cli-5mM_long.hoc
                            
:  Vector stream of events

NEURON {
	THREADSAFE
	ARTIFICIAL_CELL VecStim
	POINTER ptr
}

ASSIGNED {
	index
	etime (ms)
	ptr
}


INITIAL {
	index = 0
	element()
	if (index > 0) {
		net_send(etime - t, 1)
	}
}

NET_RECEIVE (w) {
	if (flag == 1) {
		net_event(t)
		element()
		if (index > 0) {
			net_send(etime - t, 1)
		}
	}
}

DESTRUCTOR {
VERBATIM
	void* vv = (void*)(_p_ptr);
        if (vv) {
		hoc_obj_unref(*vector_pobj(vv));
	}
ENDVERBATIM
}

PROCEDURE element() {
VERBATIM
  { void* vv; int i, size; double* px;
	i = (int)index;
	if (i >= 0) {
		vv = (void*)(_p_ptr);
		if (vv) {
			size = vector_capacity(vv);
			px = vector_vec(vv);
			if (i < size) {
				etime = px[i];
				index += 1.;
			}else{
				index = -1.;
			}
		}else{
			index = -1.;
		}
	}
  }
ENDVERBATIM
}

PROCEDURE play() {
VERBATIM
	void** pv;
	void* ptmp = NULL;
	if (ifarg(1)) {
		ptmp = vector_arg(1);
		hoc_obj_ref(*vector_pobj(ptmp));
	}
	pv = (void**)(&_p_ptr);
	if (*pv) {
		hoc_obj_unref(*vector_pobj(*pv));
	}
	*pv = ptmp;
ENDVERBATIM
}

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