Synaptic vesicle fusion model (Church et al 2021)

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These parameter files define Cell simulations of glutamate release and receptor binding at synapses. Four basic models are included that vary, the pore diameter of a fusing vesicle from full fusion (FullFusion) to a variable sized pore from a small as 0.4nm (DelayFusion), that vary the umber of fusing vesicles (Multivesicular) or that vary the position of the fusing vesicle with the post synaptic glutamate receptors (Clustered receptors). Our work demonstrates that experimental effects on release and low affinity antagonism are well-fit by reduced release rates of glutamate from a restricted pore.
1 . Church E, Hamid E, Zurawski Z, Pocoava M, Flores-Barrera E, Cabalero A, Tseng KY, Alford S (2021) Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in presynaptic terminals J Neuroscience [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Transmitter(s): Glutamate;
Simulation Environment: MCell;
Model Concept(s): Neuromodulation;
Search NeuronDB for information about:  AMPA; NMDA; Glutamate;
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