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Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. 2021)
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Model Information
Model File
Citations
Accession:
266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 .
Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons.
J Neurophysiology
125
:1501-1516
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s):
I h;
TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
NetPyNE;
Model Concept(s):
Impedance;
Implementer(s):
Kelley, Craig;
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell
;
I h
;
TASK channel
;
/
L5PYR_Resonance-master
models
Kole
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
State and location dependence of action potential metabolic cost (Hallermann et al., 2012)
Kv1.mod
*
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
na.mod
*
Other models using na.mod:
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
nax.mod
*
Other models using nax.mod:
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Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)
cellTemplate.hoc
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