Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
models
AckerAntic
misc
gflucts
mod
ampa.mod *
ca.mod *
Ca_HVA.mod *
Cad.mod *
cadyn.mod *
CaDynamics_E2.mod *
canin.mod *
CaT.mod *
gabaa.mod *
gabab.mod *
Gfluct.mod *
Gfluctp.mod *
Gfluctp_old.mod *
Gfluctp_old2.mod *
glutamate.mod *
h_kole.mod *
h_migliore.mod *
hin.mod *
Ih.mod *
IKsin.mod *
IL.mod *
kadist.mod *
kapin.mod *
kaprox.mod *
kBK.mod *
kctin.mod *
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kv.mod *
MyExp2SynBB.mod *
na.mod *
nafx.mod *
NMDA.mod
NMDAeee.mod *
PlateauConductance.mod *
SK_E2.mod *
vecstim.mod *
vmax.mod *
ghk.inc *
                            
: Slowly inactivating K+ channel

NEURON {
	SUFFIX IKsin
	USEION k READ ki, ko WRITE ik
	RANGE gKsbar, ik, gk
	
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)
	
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
	v (mV)
	dt (ms)
	gKsbar= 0.00014 (mho/cm2) <0,1e9>
	
}


STATE {
	a b
}


ASSIGNED {
	ik (mA/cm2)
	ainf binf
	atau (ms)
	btau (ms)
	gk (mho/cm2)
	ek  (mV)
	ki (mM)
	ko  (mM)
}



INITIAL {
	rate(v)
	a = ainf
	b = binf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
		
	gk = gKsbar * a * b
	ek = 25 * log(ko/ki)
	ik = gk*(v-ek)
	
}

DERIVATIVE states {
	rate(v)
	
	a' = (ainf-a)/atau
	b' = (binf-b)/btau
}
UNITSOFF

PROCEDURE rate(v (mV)) {LOCAL va, vb, vc, vd
	
	
	va = v + 34
	vb = v + 65
	vd = v + 63.6
	

if (fabs(va)<1e-04){ va = va+0.00001 }
	   ainf = 1/(1 + exp(-va/6.5))
	   atau = 10
	  :atau=6
	

if (fabs(vb)<1e-04){ vb = vb+0.00001 }
	   binf = 1/(1 + exp(vb/6.6))

 
if (fabs(vd)<1e-04){ vd = vd+0.00001 }
	   btau = 200 + 3200 / (1 + exp(-vd/4))
	:btau = 200 + 3200 / (1 + exp(-vd/4))
}

	
UNITSON








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