Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

 Download zip file 
Help downloading and running models
Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
/
L5PYR_Resonance-master
models
AckerAntic
mod
ampa.mod *
ca.mod *
Ca_HVA.mod *
Cad.mod *
cadyn.mod *
CaDynamics_E2.mod *
canin.mod *
CaT.mod *
gabaa.mod *
gabab.mod *
Gfluctp.mod *
glutamate.mod *
h_kole.mod *
h_migliore.mod *
hin.mod *
Ih.mod *
IKsin.mod *
IL.mod *
kadist.mod *
kapin.mod *
kaprox.mod *
kBK.mod *
kctin.mod *
kdrin.mod *
kv.mod *
MyExp2SynBB.mod *
na.mod *
nafx.mod *
NMDA.mod *
NMDAeee.mod *
NMDAmajor.mod
PlateauConductance.mod *
SK_E2.mod *
vecstim.mod *
vmax.mod *
ghk.inc *
                            
TITLE K-A channel from Klee Ficker and Heinemann
COMMENT

Modified to be a low threshold, slowly inactivating current
   
   Corey Acker
   Neuroscience
   UConn Health Center

   June 2006 */

ENDCOMMENT

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
     gbar=0.01
	v (mV)
	celsius (degC)
        vhalfn=11   (mV)
        vhalfl=-56   (mV)
        a0l=0.05      (/ms)
        a0n=0.05    (/ms)
        zetan=-1.5    (1)
        zetal=3    (1)
        gmn=0.55   (1)
        gml=1   (1)
	lmin=2  (mS)
	nmin=0.1  (mS)
	pw=-1    (1)
	tq=-40
	qq=5
	q10=5
	qtl=1
	ek
}


NEURON {
	SUFFIX kl
	USEION k READ ek WRITE ik
        RANGE gbar,gka
        GLOBAL ninf,linf,taul,taun,lmin
}

STATE {
	n
        l
}

ASSIGNED {
	ik (mA/cm2)
        ninf
        linf      
        taul
        taun
        gka
}

INITIAL {
	rates(v)
	n=ninf
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	gka = gbar*n*l
	ik = gka*(v-ek)

}


FUNCTION alpn(v(mV)) {
LOCAL zeta
  zeta=zetan+pw/(1+exp((v-tq)/qq))
  alpn = exp(1.e-3*zeta*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION betn(v(mV)) {
LOCAL zeta
  zeta=zetan+pw/(1+exp((v-tq)/qq))
  betn = exp(1.e-3*zeta*gmn*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION alpl(v(mV)) {
  alpl = exp(1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) 
}

FUNCTION betl(v(mV)) {
  betl = exp(1.e-3*zetal*gml*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        n' = (ninf - n)/taun
        l' =  (linf - l)/taul
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-24)/10)
        a = alpn(v)
        taun = betn(v)/(qt*a0n*(1+a))
        if (taun<nmin) {taun=nmin}
        ninf = 1/(1 + exp(-(v+60)/20))


        taul = 0.26*(v+50)/qtl*20
        if (taul<lmin/qtl) {taul=lmin/qtl}
        linf = 1/(1+ exp((v+30)/20))

}















Loading data, please wait...