Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
models
AckerAntic
mod
ampa.mod *
ca.mod *
Ca_HVA.mod *
Cad.mod *
cadyn.mod *
CaDynamics_E2.mod *
canin.mod *
CaT.mod *
gabaa.mod *
gabab.mod *
Gfluctp.mod *
glutamate.mod *
h_kole.mod *
h_migliore.mod *
hin.mod *
Ih.mod *
IKsin.mod *
IL.mod *
kadist.mod *
kapin.mod *
kaprox.mod *
kBK.mod *
kctin.mod *
kdrin.mod *
kv.mod *
MyExp2SynBB.mod *
na.mod *
nafx.mod *
NMDA.mod *
NMDAeee.mod *
NMDAmajor.mod
PlateauConductance.mod *
SK_E2.mod *
vecstim.mod *
vmax.mod *
ghk.inc *
                            
: SK-type calcium-activated potassium current
: Reference : Kohler et al. 1996

NEURON {
       SUFFIX SK_E2
       USEION k READ ek WRITE ik
       USEION ca READ cai
       RANGE gSK_E2bar, gSK_E2, ik
}

UNITS {
      (mV) = (millivolt)
      (mA) = (milliamp)
      (mM) = (milli/liter)
}

PARAMETER {
          v            (mV)
          gSK_E2bar = .000001 (mho/cm2)
          zTau = 1              (ms)
          ek           (mV)
          cai          (mM)
}

ASSIGNED {
         zInf
         ik            (mA/cm2)
         gSK_E2	       (S/cm2)
}

STATE {
      z   FROM 0 TO 1
}

BREAKPOINT {
           SOLVE states METHOD cnexp
           gSK_E2  = gSK_E2bar * z
           ik   =  gSK_E2 * (v - ek)
}

DERIVATIVE states {
        rates(cai)
        z' = (zInf - z) / zTau
}

PROCEDURE rates(ca(mM)) {
          if(ca < 1e-7){
	              ca = ca + 1e-07
          }
          zInf = 1/(1 + (0.00043 / ca)^4.8)
}

INITIAL {
        rates(cai)
        z = zInf
}

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