Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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L5PYR_Resonance-master
models
AckerAntic
mod
ampa.mod *
ca.mod *
Ca_HVA.mod *
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cadyn.mod *
CaDynamics_E2.mod *
canin.mod *
CaT.mod *
gabaa.mod *
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glutamate.mod *
h_kole.mod *
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hin.mod *
Ih.mod *
IKsin.mod *
IL.mod *
kadist.mod *
kapin.mod *
kaprox.mod *
kBK.mod *
kctin.mod *
kdrin.mod *
kv.mod *
MyExp2SynBB.mod *
na.mod *
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NMDAmajor.mod
PlateauConductance.mod *
SK_E2.mod *
vecstim.mod *
vmax.mod *
ghk.inc *
                            
: Delayed rectifier K+ channel

NEURON {
	SUFFIX kdrin
	USEION k READ ki, ko WRITE ik
	RANGE gkdrbar, ik, gk
	
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
	v (mV)
	dt (ms)
	gkdrbar= 0.0338 (mho/cm2) <0,1e9>
	
	
}

STATE {
	n
}

ASSIGNED {
	ik (mA/cm2)
	inf
	tau (ms)
	gk (mho/cm2)
	ek (mV)
	ki (mM)
	ko (mM)

}


INITIAL {
	rate(v)
	n = inf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	gk= gkdrbar*n*n*n*n
	ek = 25 * log(ko/ki)
	ik = gk*(v-ek)
	
}

DERIVATIVE states {
	rate(v)
	n' = (inf-n)/tau
}

UNITSOFF

FUNCTION alf(v){ LOCAL va 
	
	   va=v-13
	if (fabs(va)<1e-04){
	   va=va+0.0001
		alf= (-0.018*va)/(-1+exp(-(va/25)))
	} else {
	  	alf = (-0.018*(v-13))/(-1+exp(-((v-13)/25)))
	}
}


FUNCTION bet(v) { LOCAL vb 
	
	  vb=v-23
	if (fabs(vb)<1e-04){
	  vb=vb+0.0001
		bet= (0.0054*vb)/(-1+exp(vb/12))
	} else {
	  	bet = (0.0054*(v-23))/(-1+exp((v-23)/12))
	}
}	






PROCEDURE rate(v (mV)) {LOCAL q10, sum, aa, ab
	
	aa=alf(v) ab=bet(v) 
	
	sum = aa+ab
	inf = aa/sum
	tau = 1/(sum)
	
	
}

UNITSON	




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