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Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
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Model Information
Model File
Citations
Accession:
266864
Neuronal firing patterns are crucial to underpin circuit level behaviors. In cerebellar Purkinje cells (PCs), both spike rates and pauses are used for behavioral coding, but the cellular mechanisms causing code transitions remain unknown. We use a well-validated PC model to explore the coding strategy that individual PCs use to process parallel fiber (PF) inputs. We find increasing input intensity shifts PCs from linear rate-coders to burst-pause timing-coders by triggering localized dendritic spikes. We validate dendritic spike properties with experimental data, elucidate spiking mechanisms, and predict spiking thresholds with and without inhibition. Both linear and burst-pause computations use individual branches as computational units, which challenges the traditional view of PCs as linear point neurons. Dendritic spike thresholds can be regulated by voltage state, compartmentalized channel modulation, between-branch interaction and synaptic inhibition to expand the dynamic range of linear computation or burst-pause computation. In addition, co-activated PF inputs between branches can modify somatic maximum spike rates and pause durations to make them carry analogue signals. Our results provide new insights into the strategies used by individual neurons to expand their capacity of information processing.
Reference:
1 .
Zang Y, De Schutter E (2021) The Cellular Electrophysiological Properties Underlying Multiplexed Coding in Purkinje Cells.
J Neurosci
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Dendrite;
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
I T low threshold;
I Na,p;
I h;
I Potassium;
I Sodium;
I p,q;
I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Detailed Neuronal Models;
Synaptic Integration;
Temporal Coding;
Reaction-diffusion;
Implementer(s):
Zang, Yunliang ;
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
I Na,p
;
I T low threshold
;
I p,q
;
I h
;
I K,Ca
;
I Sodium
;
I Potassium
;
/
purkinje_pf_source_code
mod
BK_Slow.mod
*
Other models using BK_Slow.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
CaP.mod
*
Other models using CaP.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
capmax.mod
*
Other models using capmax.mod:
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
CaT.mod
*
Other models using CaT.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp_AIS.mod
*
Other models using cdp_AIS.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp_smooth.mod
*
Other models using cdp_smooth.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp_soma.mod
*
Other models using cdp_soma.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
cdp_spiny.mod
*
Other models using cdp_spiny.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
distr.mod
ih.mod
*
Other models using ih.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
Kv1.mod
*
Other models using Kv1.mod:
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
kv3.mod
*
Other models using kv3.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
kv4f.mod
*
Other models using kv4f.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
kv4s.mod
*
Other models using kv4s.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
mslo.mod
*
Other models using mslo.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
nap.mod
*
Other models using nap.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
narsg.mod
*
Other models using narsg.mod:
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
peak.mod
*
Other models using peak.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
pkjlk.mod
*
Other models using pkjlk.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
SK2.mod
*
Other models using SK2.mod:
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
syn2.mod
*
Other models using syn2.mod:
Dendritica (Vetter et al 2001)
Dendritica (Vetter et al 2001)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Purkinje neuron network (Zang et al. 2020)
Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
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