ModelDB: Human Cortical L5 Pyramidal Cell (Rich et al. 2021)

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Human Cortical L5 Pyramidal Cell (Rich et al. 2021)

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Accession:266984

This paper presents a full spiking, biophysically detailed multi-compartment model of a human cortical layer 5 (L5) pyramidal cell, where model development was primarily based on morphological and electrophysiological data from the same neuron. Focus was placed on capturing distinctly human dynamics of the h-channel and led to the articulation of a novel model of this channel's dynamics in humans. This led to an explanation for the surprising lack of subthreshold resonance seen in these cells in the human as opposed to rodent setting.
Reference:
1 . Rich S, Moradi Chameh H, Sekulic V, Valiante TA, Skinner FK (2021) Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons. Cereb Cortex 31:845-872 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortex layer 5 pyramidal cell; Hodgkin-Huxley neuron;
Channel(s):	I h; I M; I Na,p; I Na,t; I K; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Active Dendrites; Detailed Neuronal Models;
Implementer(s):	Rich, Scott [sbrich at umich.edu];