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Cellular and Synaptic Mechanisms Differentiate Mitral & Superficial Tufted Cells (Jones et al 2020)

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Accession:267013
"To evaluate how... different electrophysiological aspects contributed to spiking of the output MCs and sTCs, we used computational modeling. By exchanging the different cell properties in our modeled MCs and sTCs, we could evaluate each property's contribution to spiking differences between these cell types. This analysis suggested that the higher sensitivity of spiking in sTCs vs. MCs reflected both their larger monosynaptic OSN signal as well as their higher input resistance, while their smaller prolonged currents had a modest opposing effect. Taken together, our results indicate that both synaptic and intrinsic cellular features contribute to the production of parallel output channels in the olfactory bulb."
Reference:
1 . Jones S, Zylberberg J, Schoppa N (2020) Cellular and Synaptic Mechanisms That Differentiate Mitral Cells and Superficial Tufted Cells Into Parallel Output Channels in the Olfactory Bulb. Front Cell Neurosci 14:614377 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb (accessory) mitral cell; Olfactory bulb main tufted cell external;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  Glutamate; 
load_file("stdgui.hoc")

cvode_active()
Vrest=restV
dt=0.025
tstop=1000

print "ginputmono=", ginputmono
print "ginputpoly=", ginputpoly
print "latepolyinput=", latepolyinput
v_init=restV
print "v_init=", v_init

objref volt2, time2, syn1, syn2, syn3, syn4
volt2= new Vector()
time2= new Vector()

create soma, priden, tuftden[5], secden[2]

proc init() {

topol()
segments()
geometry()
memb()
}


connect secden[0](0), soma(0)
connect secden[1](0),soma(0)
connect priden(0), soma(1)
for i=0,4 {
    connect tuftden[i](0), priden(1)
}
    soma.nseg=10
    priden.nseg=100
    for i=0,4 {
        tuftden[i].nseg=50
    }
    secden[0].nseg=30
    secden[1].nseg=30


    soma { L=5.6 diam=5.6}
    priden {L=30 diam=3}
    for i=0,4 {
    tuftden[i] {L=40 diam(0:1)=.4:.4}
    }
    secden[0] {L=60 diam=2}
    secden[1] {L=60 diam=2}

// kfasttab
objref tabkinfvec, tabninfvec, tabktauvec, tabntauvec, vvec
clipboard_retrieve("kfast_k.inf")
tabkinfvec = hoc_obj_[0]
vvec = hoc_obj_[1]
clipboard_retrieve("kfast_n.inf")
tabninfvec = hoc_obj_[0]
clipboard_retrieve("kfast_k.tau")
tabktauvec = hoc_obj_[0]
clipboard_retrieve("kfast_n.tau")
tabntauvec = hoc_obj_[0]
table_tabkinf_kfasttab(&tabkinfvec.x[0], vvec.size, &vvec.x[0])
table_tabninf_kfasttab(&tabninfvec.x[0], vvec.size, &vvec.x[0])
table_tabktau_kfasttab(&tabktauvec.x[0], vvec.size, &vvec.x[0])
table_tabntau_kfasttab(&tabntauvec.x[0], vvec.size, &vvec.x[0])

//kslowtab
objref tabkinfvecs, tabninfvecs, tabktauvecs, tabntauvecs
clipboard_retrieve("kslow_k.inf")
tabkinfvecs = hoc_obj_[0]
clipboard_retrieve("kslow_n.inf")
tabninfvecs = hoc_obj_[0]
clipboard_retrieve("kslow_k.tau")
tabktauvecs = hoc_obj_[0]
clipboard_retrieve("kslow_n.tau")
tabntauvecs = hoc_obj_[0]
table_tabkinf_kslowtab(&tabkinfvecs.x[0], vvec.size, &vvec.x[0])
table_tabninf_kslowtab(&tabninfvecs.x[0], vvec.size, &vvec.x[0])
table_tabktau_kslowtab(&tabktauvecs.x[0], vvec.size, &vvec.x[0])
table_tabntau_kslowtab(&tabntauvecs.x[0], vvec.size, &vvec.x[0])


soma {insert pas
e_pas=restV
g_pas=membres
insert nafast
insert kfasttab
insert kA
insert kslowtab
insert lcafixed
insert kca3
insert cad
depth_cad = diam/4
gnabar_nafast = 0.1532
gkbar_kfasttab = 0.1956
gkbar_kA = 0.00587
gkbar_kslowtab = 0.0028
gcabar_lcafixed = 0.0040
gkbar_kca3 = 0.0142
}
priden {insert pas
e_pas=restV
g_pas=membres

}
secden[0] {insert pas
e_pas=restV
g_pas=membres

}
secden[1] {insert pas
e_pas=restV
g_pas=membres

}

for i=0,4{
tuftden[i] {insert pas
e_pas=restV
g_pas=membres

}
}

//}



tuftden[0] {
    syn1= new Exp2Delay(1)
    syn1.onset=syn1onset
    syn1.tau1=tau1inputmono
    syn1.tau2=tau2inputmono
    syn1.gmax=ginputmono
    syn1.e=0
}




tuftden[1] {
    syn2=new Exp2Delay(1)
    syn2.onset=syn2onset
    syn2.tau1=tau1inputpoly
    syn2.tau2=tau2inputpoly
    syn2.gmax=ginputpoly
    syn2.e=0
}

tuftden[2] {
    syn3= new IClamp(1)
    syn3.del=syn3onset
    syn3.dur=900
    syn3.amp=latepolyinput
}




soma {
cvode.record(&v(0.5),volt2, time2)
}


proc init() {



    t=0

finitialize(v_init)
    fcurrent()
cvode.re_init()

}

proc advance() {
    fadvance()
    doNotify()
}

proc runc() {

run()
}

proc run() {
stdinit()
    continuerun(tstop)
    doNotify()
}

runc()

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